Technology Process of (3R,4S)-1,4-diphenyl-3-<3-(methoxycarbonyl)propionamido>-2-azetidinone
There total 9 articles about (3R,4S)-1,4-diphenyl-3-<3-(methoxycarbonyl)propionamido>-2-azetidinone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium methylate;
In
methanol;
for 0.166667h;
Ambient temperature;
DOI:10.1248/cpb.38.1601
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 79 percent / H2 / 5percent Pd-C / ethanol / 6 h / 760 Torr / Ambient temperature
2: 63 percent / TEA, trifluoroacetic anhydride / CH2Cl2 / 20 h / 0 °C
3: 85 percent / 10percent aq. HCl / methanol / 2 h / 55 °C
4: 89 percent / Jones reagent / acetone / 2 h / Ambient temperature
5: 0.8 g / K2CO3 / dimethylformamide / 2.5 h / 50 °C
6: 590 mg / acetic acid; H2O; ethyl acetate / 3 h / 50 °C
7: 83 percent / Jones reagent / acetone / 1.5 h / Ambient temperature
8: 84 percent / NaOMe / methanol / 0.17 h / Ambient temperature
With
hydrogenchloride; jones reagent; TEA; hydrogen; sodium methylate; potassium carbonate; trifluoroacetic anhydride;
palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.38.1601
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 63 percent / TEA, trifluoroacetic anhydride / CH2Cl2 / 20 h / 0 °C
2: 85 percent / 10percent aq. HCl / methanol / 2 h / 55 °C
3: 89 percent / Jones reagent / acetone / 2 h / Ambient temperature
4: 0.8 g / K2CO3 / dimethylformamide / 2.5 h / 50 °C
5: 590 mg / acetic acid; H2O; ethyl acetate / 3 h / 50 °C
6: 83 percent / Jones reagent / acetone / 1.5 h / Ambient temperature
7: 84 percent / NaOMe / methanol / 0.17 h / Ambient temperature
With
hydrogenchloride; jones reagent; TEA; sodium methylate; potassium carbonate; trifluoroacetic anhydride;
In
methanol; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.38.1601
