Technology Process of (3R,14S)-15-Benzyloxy-3,14-bis-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-pentadecane-6,7,10-trione
There total 20 articles about (3R,14S)-15-Benzyloxy-3,14-bis-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-pentadecane-6,7,10-trione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ruthenium(IV) oxide; sodium periodate;
In
tetrachloromethane; water; acetonitrile;
at 25 ℃;
for 0.666667h;
DOI:10.1016/S0040-4039(97)01725-5
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 94 percent / imidazole / CH2Cl2 / 20 h / 0 - 22 °C
2: 91 percent / BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.5 h / 0 °C
3: 83 percent / TBAF / tetrahydrofuran / 32 h / -20 °C
4: (COCl)2, DMSO, Et3N / CH2Cl2 / 1 h / -78 °C
5: BuLi / tetrahydrofuran / 1 h / -78 °C
6: (COCl)2, DMSO, Et3N / CH2Cl2 / 2 h / -78 °C
7: Al(Hg) / tetrahydrofuran; H2O / 23 h / 25 °C
8: 72 percent / RuO2*H2O, NaIO4 / CCl4; acetonitrile; H2O / 0.67 h / 25 °C
With
1H-imidazole; ruthenium(IV) oxide; sodium periodate; aluminum amalgam; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(97)01725-5
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 91 percent / BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.5 h / 0 °C
2: 83 percent / TBAF / tetrahydrofuran / 32 h / -20 °C
3: (COCl)2, DMSO, Et3N / CH2Cl2 / 1 h / -78 °C
4: BuLi / tetrahydrofuran / 1 h / -78 °C
5: (COCl)2, DMSO, Et3N / CH2Cl2 / 2 h / -78 °C
6: Al(Hg) / tetrahydrofuran; H2O / 23 h / 25 °C
7: 72 percent / RuO2*H2O, NaIO4 / CCl4; acetonitrile; H2O / 0.67 h / 25 °C
With
ruthenium(IV) oxide; sodium periodate; aluminum amalgam; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(97)01725-5
