Technology Process of 2-allyloxycarbonylamino-(2S)-methyl-3-phenylpropionic acid
There total 3 articles about 2-allyloxycarbonylamino-(2S)-methyl-3-phenylpropionic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / ethanol; water / 1 h / 20 °C
1.2: 48 h / Dean-Stark trap; Reflux
2.1: boron trifluoride diethyl etherate / dichloromethane / 144 h / 5 °C
3.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / -78 °C
3.2: -70 °C
4.1: sodium hydroxide / methanol / 3 h / Reflux
With
boron trifluoride diethyl etherate; potassium hexamethylsilazane; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;
DOI:10.1055/s-0031-1289901
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: boron trifluoride diethyl etherate / dichloromethane / 144 h / 5 °C
2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / -78 °C
2.2: -70 °C
3.1: sodium hydroxide / methanol / 3 h / Reflux
With
boron trifluoride diethyl etherate; potassium hexamethylsilazane; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1055/s-0031-1289901
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / -78 °C
1.2: -70 °C
2.1: sodium hydroxide / methanol / 3 h / Reflux
With
potassium hexamethylsilazane; sodium hydroxide;
In
tetrahydrofuran; methanol; toluene;
DOI:10.1055/s-0031-1289901
