(R)-2,3-dihydroxy-2-methylpropyl 4-methoxybenzoate

Base Information

Chemical Name:(R)-2,3-dihydroxy-2-methylpropyl 4-methoxybenzoate
CAS No.:1057675-74-7
Molecular Formula:C₁₂H₁₆O₅
Molecular Weight:240.256
Hs Code.:

Synonyms:(R)-2,3-dihydroxy-2-methylpropyl 4-methoxybenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2,3-dihydroxy-2-methylpropyl 4-methoxybenzoate

Chemical Property:

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Technology Process of (R)-2,3-dihydroxy-2-methylpropyl 4-methoxybenzoate

There total 4 articles about (R)-2,3-dihydroxy-2-methylpropyl 4-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 34301-32-1
2-methyl-2-propenyl-4-methoxybenzoate

: 1057675-74-7
(R)-2,3-dihydroxy-2-methylpropyl 4-methoxybenzoate

Guidance literature:: With potassium osmate(VI) dihydrate; water; potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III); In tert-butyl alcohol; at 0 ℃; for 4.5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1038/ja.2011.90

Reference yield:

: 34301-32-1
2-methyl-2-propenyl-4-methoxybenzoate

: 1057675-74-7
(R)-2,3-dihydroxy-2-methylpropyl 4-methoxybenzoate

: 161578-88-7
(S)-3-((4-methoxybenzoyl)oxy)-2-methyl-1,2-propanediol

Guidance literature:: With AD-mix β; In water; tert-butyl alcohol; at 0 ℃; Overall yield = 88 %; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c4ob00621f

Reference yield:

: 100-09-4
4-methoxybenzoic acid

: 1057675-74-7
(R)-2,3-dihydroxy-2-methylpropyl 4-methoxybenzoate

: 161578-88-7
(S)-3-((4-methoxybenzoyl)oxy)-2-methyl-1,2-propanediol

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; triethylamine; ethylene dichloride hydrochloride / dichloromethane / 0.5 h / 23 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: AD-mix β / water; tert-butyl alcohol / 0 °C / Inert atmosphere

With dmap; ethylene dichloride hydrochloride; AD-mix β; triethylamine; In dichloromethane; water; tert-butyl alcohol; 2.1: |Sharpless Dihydroxylation;
DOI:10.1039/c4ob00621f