N-[6-[2-(4-Nitro-phenyl)-ethoxy]-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-isobutyramide

Base Information

Chemical Name:N-[6-[2-(4-Nitro-phenyl)-ethoxy]-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-isobutyramide
CAS No.:166593-48-2
Molecular Formula:C₃₇H₅₈N₆O₉Si₂
Molecular Weight:787.073
Hs Code.:

N-[6-[2-(4-Nitro-phenyl)-ethoxy]-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-isobutyramide

Synonyms:N-[6-[2-(4-Nitro-phenyl)-ethoxy]-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-isobutyramide

Suppliers and Price of N-[6-[2-(4-Nitro-phenyl)-ethoxy]-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-isobutyramide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[6-[2-(4-Nitro-phenyl)-ethoxy]-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-isobutyramide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[6-[2-(4-Nitro-phenyl)-ethoxy]-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-isobutyramide

There total 5 articles about N-[6-[2-(4-Nitro-phenyl)-ethoxy]-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 143325-60-4
N²-Isobutyryl-O⁶-[2-(4-nitrophenylethyl)]guanine

: 166593-40-4
2,2,2-Trichloro-acetimidic acid (2S,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl ester

: 166593-48-2
N-[6-[2-(4-Nitro-phenyl)-ethoxy]-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-isobutyramide

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; Ambient temperature;
DOI:10.1016/S0040-4039(00)75987-9

Reference yield:

: 50-69-1
D-ribose

: 166593-48-2
N-[6-[2-(4-Nitro-phenyl)-ethoxy]-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-isobutyramide

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / HCl / 20 °C

2: 90 percent / pyridine / Ambient temperature

3: 1.) DMAP; 2.) PPh₃, Pd(OAc)2 / 1.) acetonitrile, RT; 2.) toluene, reflux

4: 92 percent / H₂ / 10 percent Pd/C / ethyl acetate / Ambient temperature

5: 75 percent / DBU / 1,2-dichloro-ethane / Ambient temperature

6: 86 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / Ambient temperature

With pyridine; hydrogenchloride; dmap; palladium diacetate; trimethylsilyl trifluoromethanesulfonate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; palladium on activated charcoal; In ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(00)75987-9

Reference yield:

: 117363-13-0
benzyl 3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranoside

: 166593-48-2
N-[6-[2-(4-Nitro-phenyl)-ethoxy]-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-propoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-yl]-isobutyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) DMAP; 2.) PPh₃, Pd(OAc)2 / 1.) acetonitrile, RT; 2.) toluene, reflux

2: 92 percent / H₂ / 10 percent Pd/C / ethyl acetate / Ambient temperature

3: 75 percent / DBU / 1,2-dichloro-ethane / Ambient temperature

4: 86 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / Ambient temperature

With dmap; palladium diacetate; trimethylsilyl trifluoromethanesulfonate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; palladium on activated charcoal; In ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(00)75987-9