6-chloro-2-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

Base Information

Chemical Name:6-chloro-2-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
CAS No.:1334297-54-9
Molecular Formula:C₁₉H₁₉Cl₂N₃O₆
Molecular Weight:456.282
Hs Code.:

Synonyms:6-chloro-2-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

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Chemical Property of 6-chloro-2-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

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Technology Process of 6-chloro-2-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

There total 8 articles about 6-chloro-2-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613149-84-0
C₂₇H₂₇Cl₂N₃O₁₀

: 1334297-54-9
6-chloro-2-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2014.04.036

Reference yield:

: 866605-98-3
C₃₇H₄₃ClO₁₀Si

: 1334297-54-9
6-chloro-2-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 15 h / 20 °C / Inert atmosphere

3: potassium carbonate / methanol / 18 h / 20 °C

With tetrabutyl ammonium fluoride; potassium carbonate; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; 2: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2014.04.036

Reference yield:

: 866605-96-1
(3R,4S,5S,6R)-2-(3-((tert-butyldiphenylsilyloxy)methyl)-4-chlorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

: 1334297-54-9
6-chloro-2-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 2 h / 0 °C

2: pyridine; dmap / chloroform / 20 °C

3: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

4: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 15 h / 20 °C / Inert atmosphere

5: potassium carbonate / methanol / 18 h / 20 °C

With pyridine; triethylsilane; dmap; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; potassium carbonate; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; chloroform; 4: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2014.04.036