2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-2-phenylacetamide

Base Information

Chemical Name:2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-2-phenylacetamide
CAS No.:1430836-27-3
Molecular Formula:C₂₀H₁₈BrN₃O₆
Molecular Weight:476.283
Hs Code.:

Synonyms:2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-2-phenylacetamide

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Chemical Property of 2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-2-phenylacetamide

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Technology Process of 2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-2-phenylacetamide

There total 8 articles about 2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.3%

: 1446416-11-0
C₂₁H₁₉BrN₂O₆

: 1430836-27-3
2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-2-phenylacetamide

Guidance literature:: With hydroxylamine potassium salt; In methanol; for 1.5h;
DOI:10.1016/j.bmc.2012.06.024

Reference yield:

: 66475-83-0
N-(4-bromophenyl)-2-(hydroxyimino) acetamide

: 1430836-27-3
2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-2-phenylacetamide

Guidance literature:: Multi-step reaction with 7 steps

1: sulfuric acid / 0.5 h / 60 - 90 °C

2: toluene-4-sulfonic acid / toluene / 5 h / 130 °C

3: potassium carbonate; tetrabutylammomium bromide; potassium iodide / acetone / 6 h / 56 °C

4: potassium hydroxide / water; ethanol

5: 4-methyl-morpholine / tetrahydrofuran / 0.5 h / -15 °C

6: 4-methyl-morpholine / tetrahydrofuran / 13 h / -15 - 20 °C

7: hydroxylamine potassium salt / methanol / 1.5 h

With 4-methyl-morpholine; hydroxylamine potassium salt; sulfuric acid; tetrabutylammomium bromide; potassium carbonate; toluene-4-sulfonic acid; potassium iodide; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; water; acetone; toluene;
DOI:10.1016/j.bmc.2012.06.024

Reference yield:

: 331267-94-8
C₁₂H₁₀BrNO₅

: 1430836-27-3
2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-2-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine / tetrahydrofuran / 0.5 h / -15 °C

2: 4-methyl-morpholine / tetrahydrofuran / 13 h / -15 - 20 °C

3: hydroxylamine potassium salt / methanol / 1.5 h

With 4-methyl-morpholine; hydroxylamine potassium salt; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2012.06.024