(2R,3R,5S)-1-tert-butoxycarbonyl-2-tetrahydropyranyloxymethyl-3-phenylsulfonyl-5-benzyloxymethylpyrrolidine

Base Information

Chemical Name:(2R,3R,5S)-1-tert-butoxycarbonyl-2-tetrahydropyranyloxymethyl-3-phenylsulfonyl-5-benzyloxymethylpyrrolidine
CAS No.:253776-39-5
Molecular Formula:C₂₉H₃₉NO₇S
Molecular Weight:545.697
Hs Code.:

Synonyms:(2R,3R,5S)-1-tert-butoxycarbonyl-2-tetrahydropyranyloxymethyl-3-phenylsulfonyl-5-benzyloxymethylpyrrolidine

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Chemical Property of (2R,3R,5S)-1-tert-butoxycarbonyl-2-tetrahydropyranyloxymethyl-3-phenylsulfonyl-5-benzyloxymethylpyrrolidine

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Technology Process of (2R,3R,5S)-1-tert-butoxycarbonyl-2-tetrahydropyranyloxymethyl-3-phenylsulfonyl-5-benzyloxymethylpyrrolidine

There total 2 articles about (2R,3R,5S)-1-tert-butoxycarbonyl-2-tetrahydropyranyloxymethyl-3-phenylsulfonyl-5-benzyloxymethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116611-45-1
(2R)-2-t-butoxycarbonylamino-3-phenylsulfonyl-1-(2-tetrahydropyranyloxy)propane

: 253776-34-0
(2S)-1-O-benzylglycerol-2,3-bis(trifluoromethanesulfonate)

: 253776-38-4
(2R,3S,5S)-1-tert-butoxycarbonyl-2-tetrahydropyranyloxymethyl-3-phenylsulfonyl-5-benzyloxymethylpyrrolidine

: 253776-39-5
(2R,3R,5S)-1-tert-butoxycarbonyl-2-tetrahydropyranyloxymethyl-3-phenylsulfonyl-5-benzyloxymethylpyrrolidine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -70 ℃; for 1h;
DOI:10.1021/jo991052d

Reference yield:

: 56552-80-8
(R)-3-benzyloxy-1,2-propanediol

: 253776-39-5
(2R,3R,5S)-1-tert-butoxycarbonyl-2-tetrahydropyranyloxymethyl-3-phenylsulfonyl-5-benzyloxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / pyridine / CH₂Cl₂ / 0.33 h / -30 °C

2: n-BuLi / tetrahydrofuran / 1 h / -70 °C

With pyridine; n-butyllithium; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Cyclization;
DOI:10.1021/jo991052d