(R)-methyl 2-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-3-fluorobenzylamino)-3-hydroxypropanoate

Base Information

Chemical Name:(R)-methyl 2-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-3-fluorobenzylamino)-3-hydroxypropanoate
CAS No.:1436421-40-7
Molecular Formula:C₂₅H₂₉ClF₄N₄O₄
Molecular Weight:560.976
Hs Code.:

Synonyms:(R)-methyl 2-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-3-fluorobenzylamino)-3-hydroxypropanoate

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Chemical Property of (R)-methyl 2-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-3-fluorobenzylamino)-3-hydroxypropanoate

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Technology Process of (R)-methyl 2-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-3-fluorobenzylamino)-3-hydroxypropanoate

There total 6 articles about (R)-methyl 2-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-3-fluorobenzylamino)-3-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1436426-21-9
4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 477199-77-2
4-(bromomethyl)-2-fluorobenzoic acid

: 1436421-40-7
(R)-methyl 2-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-3-fluorobenzylamino)-3-hydroxypropanoate

Guidance literature:: 4-(bromomethyl)-2-fluorobenzoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;

4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

R-(-)-serine methyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

Reference yield:

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 1436421-40-7
(R)-methyl 2-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-3-fluorobenzylamino)-3-hydroxypropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropyl alcohol / 20 °C / Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol / Reflux

3.1: ethanol; tin(ll) chloride / 1 h / 80 °C / Cooling with ice

4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 0.5 h / 20 °C

4.3: 3 h / 80 °C

With oxalyl dichloride; ethanol; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 7697-23-6
2-fluoro-4-methylbenzoic Acid

: 1436421-40-7
(R)-methyl 2-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-3-fluorobenzylamino)-3-hydroxypropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 100 °C

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 0.5 h / 20 °C

2.3: 3 h / 80 °C

With N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;