methyl 3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid

Base Information

Chemical Name:methyl 3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid
CAS No.:158062-07-8
Molecular Formula:C₂₆H₂₆N₂O₅
Molecular Weight:446.503
Hs Code.:

methyl 3-<4-<2-<N-(2-benzoxazolyl)-N-methylamino>ethoxy>phenyl>-2-benzyloxypropanoic acid

Synonyms:methyl 3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid

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Chemical Property of methyl 3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid

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Technology Process of methyl 3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid

There total 2 articles about methyl 3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 158062-06-7
methyl 3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoate

: 158062-07-8
methyl 3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid

Guidance literature:: With sodium hydroxide; In methanol;
DOI:10.1016/S0957-4166(99)00104-4

Reference yield:

: ethyl (E/Z)-3-<4-<2-ethoxy>phenyl>-2-benzyloxypropenoate

: 158062-07-8
methyl 3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / Mg, I₂ / 23 h / Ambient temperature

2: 91 percent / aq. NaOH / methanol

With sodium hydroxide; iodine; magnesium; In methanol;
DOI:10.1016/S0957-4166(99)00104-4

Reference yield:

: 158062-07-8
methyl 3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid

: (R)-(+)-3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride / benzene / 2.5 h / Heating

2: 1.) n-butyllithium / 1.) hexane, THF, -70 deg C, 10 min, 2.) hexane, THF, from -70 deg C to RT, 21 h

3: NaOMe / 0.22 h / 0 °C

4: 68 percent / 2 M aq. HCl / dioxane / 6.5 h / 90 °C

With hydrogenchloride; n-butyllithium; oxalyl dichloride; sodium methylate; In 1,4-dioxane; benzene;
DOI:10.1016/S0957-4166(99)00104-4