4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({4-phenyl-1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl}methyl)benzamide

Base Information

Chemical Name:4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({4-phenyl-1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl}methyl)benzamide
CAS No.:1093396-29-2
Molecular Formula:C₃₆H₃₂F₃N₅O₂
Molecular Weight:623.678
Hs Code.:

Synonyms:4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({4-phenyl-1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl}methyl)benzamide

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Chemical Property of 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({4-phenyl-1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl}methyl)benzamide

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Technology Process of 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({4-phenyl-1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl}methyl)benzamide

There total 7 articles about 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({4-phenyl-1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl}methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1093395-66-4
4-(5-cyano-7-isopropyl-benzooxazol-2-yl)-benzoic acid

: 1093396-30-5
({4-phenyl-1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl}methyl)amine

: 1093396-29-2
4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({4-phenyl-1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl}methyl)benzamide

Guidance literature:: 4-(5-cyano-7-isopropyl-benzooxazol-2-yl)-benzoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃;

({4-phenyl-1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl}methyl)amine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 862730-24-3
3-amino-5-bromo-4-hydroxybenzonitrile

: 1093396-29-2
4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({4-phenyl-1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl}methyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,4-dioxane / Reflux

1.2: Reflux

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 91 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 3 h / 60 °C / 517.16 Torr

4.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 1 h / 50 °C

4.2: 0.08 h

5.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

5.2: 4 h / 20 °C

With oxalyl dichloride; lithium hydroxide monohydrate; hydrogen; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1828-58-6
3-bromo-4-hydroxy-5-nitrobenzonitrile

: 1093396-29-2
4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-({4-phenyl-1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl}methyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyrographite / iron(III) chloride / methanol / 0.25 h / 65 °C

1.2: 2 h / Reflux

2.1: 1,4-dioxane / Reflux

2.2: Reflux

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 91 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 3 h / 60 °C / 517.16 Torr

5.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 1 h / 50 °C

5.2: 0.08 h

6.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

6.2: 4 h / 20 °C

With oxalyl dichloride; lithium hydroxide monohydrate; hydrogen; sodium carbonate; pyrographite; iron(III) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;