2-[2,5-bis(2-phenyl-1-ethynyl)-4-(tetrahydro-2H-2-pyranyloxy)phenoxy]tetrahydro-2H-pyran

Base Information

• Chemical Name: 2-[2,5-bis(2-phenyl-1-ethynyl)-4-(tetrahydro-2H-2-pyranyloxy)phenoxy]tetrahydro-2H-pyran
• CAS No.: 956315-16-5
• Molecular Formula: C₃₂H₃₀O₄
• Molecular Weight: 478.588
• Mol file: 956315-16-5.mol

Synonyms:2-[2,5-bis(2-phenyl-1-ethynyl)-4-(tetrahydro-2H-2-pyranyloxy)phenoxy]tetrahydro-2H-pyran

Chemical Property of 2-[2,5-bis(2-phenyl-1-ethynyl)-4-(tetrahydro-2H-2-pyranyloxy)phenoxy]tetrahydro-2H-pyran

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-[2,5-bis(2-phenyl-1-ethynyl)-4-(tetrahydro-2H-2-pyranyloxy)phenoxy]tetrahydro-2H-pyran

There total 2 articles about 2-[2,5-bis(2-phenyl-1-ethynyl)-4-(tetrahydro-2H-2-pyranyloxy)phenoxy]tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

phenylacetylene (536-74-3) + 2-(2,5-dibromo-4-(tetrahydro-2H-pyran-2-yloxy)phenoxy)tetrahydro-2H-pyran (195990-17-1) → 2-[2,5-bis(2-phenyl-1-ethynyl)-4-(tetrahydro-2H-2-pyranyloxy)phenoxy]tetrahydro-2H-pyran (956315-16-5)

Guidance literature:

With piperidine; triethylamine; triphenylphosphine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 80 ℃; for 22h;

DOI:10.1021/ja074365w

Reference yield:

tributylstannylethynylbenzene (3757-88-8) + 2-(2,5-dibromo-4-(tetrahydro-2H-pyran-2-yloxy)phenoxy)tetrahydro-2H-pyran (195990-17-1) → 2-[2,5-bis(2-phenyl-1-ethynyl)-4-(tetrahydro-2H-2-pyranyloxy)phenoxy]tetrahydro-2H-pyran (956315-16-5)

Guidance literature:

tributylstannylethynylbenzene; 2-(2,5-dibromo-4-(tetrahydro-2H-pyran-2-yloxy)phenoxy)tetrahydro-2H-pyran; Pd(PPh₃); In 1,4-dioxane; at 110 ℃;

With potassium fluoride; In diethyl ether; at 20 ℃;

DOI:10.1002/adsc.200404233

upstream raw materials:

tributylstannylethynylbenzene

2-(2,5-dibromo-4-(tetrahydro-2H-pyran-2-yloxy)phenoxy)tetrahydro-2H-pyran

phenylacetylene