Technology Process of (4S,5S)-3-benzyl-4-(2',3'-dihydroxypropyl)-5-pentyl-2-oxazolidinone
There total 6 articles about (4S,5S)-3-benzyl-4-(2',3'-dihydroxypropyl)-5-pentyl-2-oxazolidinone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
osmium(VIII) oxide; N-methyl-2-indolinone;
In
tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1021/ol016810c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaH / tetrahydrofuran / 0.17 h / 20 °C
1.2: tetrahydrofuran / 1.5 h / Heating
2.1: triphenylphosphine; imidazole; iodine / diethyl ether; acetonitrile; benzene / 0 - 20 °C
3.1: CuI; HMPA / tetrahydrofuran / 1 h / -30 °C
4.1: aq. osmium tetroxide; N-methylmorpholine N-oxide / benzene; 2-methyl-propan-2-ol; tetrahydrofuran / 20 h
With
1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; osmium(VIII) oxide; iodine; sodium hydride; 4-methylmorpholine N-oxide; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/ja0288800
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triphenylphosphine; imidazole; iodine / diethyl ether; acetonitrile; benzene / 0 - 20 °C
2: CuI; HMPA / tetrahydrofuran / 1 h / -30 °C
3: aq. osmium tetroxide; N-methylmorpholine N-oxide / benzene; 2-methyl-propan-2-ol; tetrahydrofuran / 20 h
With
1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; osmium(VIII) oxide; iodine; 4-methylmorpholine N-oxide; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/ja0288800
