methyl (R)-4-amino>pentanoate

Base Information

• Chemical Name: methyl (R)-4-amino>pentanoate
• CAS No.: 123993-05-5
• Molecular Formula: C₁₆H₂₀F₃NO₄
• Molecular Weight: 347.334
• Mol file: 123993-05-5.mol

Synonyms:methyl (R)-4-amino>pentanoate

Chemical Property of methyl (R)-4-amino>pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (R)-4-amino>pentanoate

There total 9 articles about methyl (R)-4-amino>pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-methoxytrifluoromethylphenylacetyl chloride (20445-33-4,39637-99-5) + methyl (R)-4-aminopentanoate hydrochloride (123993-04-4) → methyl (R)-4-amino>pentanoate (123993-05-5)

Guidance literature:

With pyridine; overnight;

DOI:10.1021/ja00158a052

Reference yield:

(S)-Pyroglutaminol (17342-08-4) → methyl (R)-4-amino>pentanoate (123993-05-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 72.8 percent / CBr₄, Ph₃P / acetonitrile / Ambient temperature

2: 91.7 percent / tributyltin hydride, AIBN / toluene / 5 h / 80 °C

3: 90.6 percent / 6 N HCl / 8 h / Heating

4: 100 percent / thionyl chloride / 72 h / Ambient temperature

5: 100 percent / pyridine / overnight

With pyridine; hydrogenchloride; thionyl chloride; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; tri-n-butyl-tin hydride; triphenylphosphine; In toluene; acetonitrile;

DOI:10.1021/ja00158a052

Reference yield:

4-aminopentanoic acid (13880-74-5,349548-27-2) → methyl (RS)-4-amino>pentanoate (123993-05-5,123993-18-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / thionyl chloride / methanol / 72 h / Ambient temperature

2: pyridine

With pyridine; thionyl chloride; In methanol;

DOI:10.1021/ja00158a052

upstream raw materials:

(R)-methoxytrifluoromethylphenylacetyl chloride

γ-aminovaleric acid methyl ester hydrochloride

4-aminopentanoic acid

methyl (R)-4-aminopentanoate hydrochloride