2-(N-benzyl-N-(benzyloxycarbonyl))ethanolamine

Base Information

• Chemical Name: 2-(N-benzyl-N-(benzyloxycarbonyl))ethanolamine
• CAS No.: 120005-03-0
• Molecular Formula: C₁₇H₁₉NO₃
• Molecular Weight: 285.343
• Mol file: 120005-03-0.mol

Synonyms:2-(N-benzyl-N-(benzyloxycarbonyl))ethanolamine

Chemical Property of 2-(N-benzyl-N-(benzyloxycarbonyl))ethanolamine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(N-benzyl-N-(benzyloxycarbonyl))ethanolamine

There total 1 articles about 2-(N-benzyl-N-(benzyloxycarbonyl))ethanolamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

benzyl chloroformate (501-53-1,94274-21-2) + N-Benzylethanolamine (104-63-2) → 2-(N-benzyl-N-(benzyloxycarbonyl))ethanolamine (120005-03-0)

Guidance literature:

With sodium hydrogencarbonate; In water; ethyl acetate; at 0 ℃; for 0.333333h;

DOI:10.1021/ol025644l

Reference yield: 98.0%

2-(N-benzyl-N-(benzyloxycarbonyl))ethanolamine (120005-03-0) → benzyl benzyl(2-oxoethyl)carbamate (166947-03-1)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/ol025644l

Reference yield: 95.0%

5-tert-butyl-2-methylphenyl 2-O-benzoyl-4,6-O-benzylidene-3-O-tertbutyldimethylsilyl-β-D-glucopyranosyl-(1→4)-2,3-di-O-benzoyl-6-O-benzyl-1-thio-β-D-glucopyranoside + 2-(N-benzyl-N-(benzyloxycarbonyl))ethanolamine (120005-03-0) → C70H73NO17Si

Guidance literature:

With N-iodo-succinimide; trifluorormethanesulfonic acid; In dichloromethane; at -10 - 0 ℃; for 6h; Molecular sieve; Inert atmosphere;

DOI:10.1021/acs.orglett.9b03851

upstream raw materials:

benzyl chloroformate

N-Benzylethanolamine

Downstream raw materials:

3-[2-(benzyl-benzyloxycarbonyl-amino)-ethoxy]-2-tert-butoxycarbonylamino-propionic acid methyl ester

benzyl benzyl(2-oxoethyl)carbamate

C₃₄H₄₁NO₁₄