2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)phenoxy)acetic acid

Base Information

Chemical Name:2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)phenoxy)acetic acid
CAS No.:317318-58-4
Molecular Formula:C₂₁H₁₈F₃NO₄S
Molecular Weight:437.439
Hs Code.:

Synonyms:2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)phenoxy)acetic acid

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Chemical Property of 2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)phenoxy)acetic acid

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Technology Process of 2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)phenoxy)acetic acid

There total 7 articles about 2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)phenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 317318-58-4
2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)phenoxy)acetic acid

Guidance literature:

Reference yield: 61.0%

: 317319-10-1
methyl (4-hydroxy-2-methylphenoxy)acetate

: 317318-97-1
5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

: 317318-58-4
2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)phenoxy)acetic acid

Guidance literature:: methyl (4-hydroxy-2-methylphenoxy)acetate; 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole; With potassium carbonate; potassium iodide; In acetonitrile; at 45 ℃; for 12h;

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 0 ℃; for 4h;
DOI:10.1016/j.ejmech.2018.12.069

Reference yield:

: 175277-03-9
4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylic acid ethyl ester

: 317318-58-4
2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol; tetrahydrofuran / Reflux

1.2: 4 h / 40 °C

2.1: potassium carbonate; potassium iodide / acetonitrile / 12 h / 45 °C

2.2: 4 h / 0 °C

With sodium tetrahydroborate; potassium carbonate; potassium iodide; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/j.ejmech.2018.12.069