2-FLUOROFLUORENE

Base Information

• Chemical Name: 2-FLUOROFLUORENE
• CAS No.: 343-43-1
• Molecular Formula: C13H9F
• Molecular Weight: 184.213
• Hs Code.: 2903999090
• Mol file: 343-43-1.mol

Synonyms:Fluorene,2-fluoro- (6CI,7CI,8CI);2-Fluorofluorene;

Chemical Property of 2-FLUOROFLUORENE

Chemical Property:

• Melting Point: 98 °C
• Boiling Point: 298.5 °C at 760 mmHg
• Flash Point: 109.9 °C
• PSA: 0.00000
• Density: 1.207 g/cm³
• LogP: 3.39690

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluorofluorene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUOROFLUORENE

There total 36 articles about 2-FLUOROFLUORENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromo-4’-fluoro-1,1’-biphenyl (89346-54-3) + diazomethyl-trimethyl-silane (18107-18-1) → 2-fluoro-9H-fluorene (343-43-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; In 1,4-dioxane; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acscatal.6b03562

Reference yield: 86.0%

4-fluoroboronic acid (1765-93-1) + 1-Bromo-2-bromomethyl-benzene (3433-80-5) → 2-fluoro-9H-fluorene (343-43-1)

Guidance literature:

With potassium phosphate; palladium diacetate; lithium chloride; tricyclohexylphosphine; Trimethylacetic acid; In tetrahydrofuran; at 120 ℃; for 12h; Reagent/catalyst; Temperature; Solvent; chemoselective reaction; Inert atmosphere; Schlenk technique; Molecular sieve; Glovebox;

DOI:10.1002/asia.201501135

Reference yield: 85.0%

3-(2-trimethylsilylbenzyl)fluorobenzene → 2-fluoro-9H-fluorene (343-43-1)

Guidance literature:

With [bis(acetoxy)iodo]benzene; (R)-10-camphorsulfonic acid; tetrahydrothiophene gold(III) bromide; In methanol; chloroform; at 27 ℃; for 2h; Schlenk technique; Inert atmosphere;

DOI:10.1021/jacv6b10018

upstream raw materials:

9H-fluorene

o-trifluoromethylphenyl bromide

1-Bromo-4-fluorobenzene

2-fluoro-9H-fluoren-9-one

Downstream raw materials:

2-fluoro-7-nitro-fluorene

7-fluoro-fluoren-2-ylamine

2-(Chloro-phenyl-methyl)-7-fluoro-9H-fluorene

AL 1567

Refernces

• 1、 Akhmetov, Vladimir,Amsharov, Konstantin,F?rtsch, Andreas,Feofanov, Mikhail. "Solid-state construction of zigzag periphery: Via intramolecular C-H insertion induced by alumina-mediated C-F activation". supporting information. p. 12325 - 12328. Retrieved 2021/11/30.
• 2、 Corrie, Tom J. A.,Ball, Liam T.,Russell, Christopher A.,Lloyd-Jones, Guy C.. "Au-catalyzed biaryl coupling to generate 5- to 9-membered rings: Turnover-limiting reductive elimination versus π-complexation". . p. 245 - 254. Retrieved 2017/05/29.