ethyl 1,2,6,7,8,8a-hexahydro-1-(4-nitrophenyl)-4-isoquinolinecarboxylate

Base Information

• Chemical Name: ethyl 1,2,6,7,8,8a-hexahydro-1-(4-nitrophenyl)-4-isoquinolinecarboxylate
• CAS No.: 244239-09-6
• Molecular Formula: C₁₈H₂₀N₂O₄
• Molecular Weight: 328.368
• Mol file: 244239-09-6.mol

Synonyms:ethyl 1,2,6,7,8,8a-hexahydro-1-(4-nitrophenyl)-4-isoquinolinecarboxylate

Chemical Property of ethyl 1,2,6,7,8,8a-hexahydro-1-(4-nitrophenyl)-4-isoquinolinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1,2,6,7,8,8a-hexahydro-1-(4-nitrophenyl)-4-isoquinolinecarboxylate

There total 2 articles about ethyl 1,2,6,7,8,8a-hexahydro-1-(4-nitrophenyl)-4-isoquinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(1-Cyclohexen-1-yl)pyrrolidine (1125-99-1) + (E)-3-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-amino}-acrylic acid ethyl ester (182418-46-8) → ethyl 1,2,6,7,8,8a-hexahydro-1-(4-nitrophenyl)-4-isoquinolinecarboxylate (244239-09-6)

Guidance literature:

In chloroform; at 20 ℃; for 1h;

DOI:10.1021/jo9902650

Reference yield:

4-(Ethoxycarbonyl)-1,1-diphenyl-1-methyl-2-aza-1λ5-phosphabuta-1,3-diene (152975-95-6) → ethyl 1,2,6,7,8,8a-hexahydro-1-(4-nitrophenyl)-4-isoquinolinecarboxylate (244239-09-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / CHCl₃ / 2 h / 20 °C

2: 95 percent / CHCl₃ / 1 h / 20 °C

In chloroform; 1: Substitution / 2: Cycloaddition;

DOI:10.1021/jo9902650

Reference yield: 90.0%

ethyl 1,2,6,7,8,8a-hexahydro-1-(4-nitrophenyl)-4-isoquinolinecarboxylate (244239-09-6) → 1-(4-nitro-phenyl)-5,6,7,8-tetrahydro-isoquinoline-4-carboxylic acid ethyl ester

Guidance literature:

With p-benzoquinone; In 1,4-dioxane; at 100 ℃; for 14h;

DOI:10.1021/jo9902650

upstream raw materials:

1-(1-Cyclohexen-1-yl)pyrrolidine

(E)-3-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-amino}-acrylic acid ethyl ester

4-(Ethoxycarbonyl)-1,1-diphenyl-1-methyl-2-aza-1λ⁵-phosphabuta-1,3-diene