2,2'-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis(((6-methylpyridin-2-yl)methyl)azanediyl)diethanol

Base Information

• Chemical Name: 2,2'-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis(((6-methylpyridin-2-yl)methyl)azanediyl)diethanol
• CAS No.: 1428897-15-7
• Molecular Formula: C₂₇H₃₆N₄O₃
• Molecular Weight: 464.608
• Mol file: 1428897-15-7.mol

Synonyms:2,2'-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis(((6-methylpyridin-2-yl)methyl)azanediyl)diethanol

Chemical Property of 2,2'-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis(((6-methylpyridin-2-yl)methyl)azanediyl)diethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2'-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis(((6-methylpyridin-2-yl)methyl)azanediyl)diethanol

There total 2 articles about 2,2'-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis(((6-methylpyridin-2-yl)methyl)azanediyl)diethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

2-((6-methylpyridin-2-yl)amino)ethanol (1178357-09-9) + 2,6-bis(chloromethyl)-4-methylphenol (5862-32-8) → 2,2'-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis(((6-methylpyridin-2-yl)methyl)azanediyl)diethanol (1428897-15-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.poly.2012.06.008

Reference yield:

6-methyl-2-pyridinecarboxaldehyde (1122-72-1) → 2,2'-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis(((6-methylpyridin-2-yl)methyl)azanediyl)diethanol (1428897-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C

2: triethylamine / dichloromethane; tetrahydrofuran / 0 - 20 °C

With sodium tetrahydroborate; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.poly.2012.06.008

Reference yield: 52.0%

sodium hexaflorophosphate + 2,2'-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis(((6-methylpyridin-2-yl)methyl)azanediyl)diethanol (1428897-15-7) + zinc(II) acetate dihydrate (5970-45-6) → [Zn2(2,2'-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis(((6-methylpyridin-2-yl)methyl)azanediyl)diethanol-H)(CH3CO2)(H2O)](PF6)2·2H2O

Guidance literature:

In methanol; at 60 ℃; for 0.666667h; Reflux;

DOI:10.1016/j.poly.2012.06.008

upstream raw materials:

2-((6-methylpyridin-2-yl)amino)ethanol

2,6-bis(chloromethyl)-4-methylphenol

6-methyl-2-pyridinecarboxaldehyde