Technology Process of (rac)-4-(2,4-difluorophenyl)-5-fluoro-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}pyrimidin-2-amine
There total 9 articles about (rac)-4-(2,4-difluorophenyl)-5-fluoro-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}pyrimidin-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium ethanolate;
In
ethanol;
at 60 ℃;
for 73.5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: ethanol / -15 - 20 °C
2: iron(III) chloride; periodic acid / acetonitrile / 20 - 30 °C
3: [bis(acetoxy)iodo]benzene; magnesium oxide; dirhodium(II) tetracarboxylate / dichloromethane / 16 h / 20 °C
4: potassium carbonate / methanol / 1 h / 20 °C
5: pyridine / 0 - 20 °C
6: hydrogenchloride; titanium(III) chloride / tetrahydrofuran / 18 h / 20 °C
7: chloro(2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct; XPhos; potassium phosphate / toluene; 1-methyl-pyrrolidin-2-one / 3 h / 130 °C / Inert atmosphere; Microwave irradiation
8: sodium ethanolate / ethanol / 73.5 h / 60 °C / Inert atmosphere
With
pyridine; hydrogenchloride; iron(III) chloride; potassium phosphate; titanium(III) chloride; dirhodium(II) tetracarboxylate; [bis(acetoxy)iodo]benzene; chloro(2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct; sodium ethanolate; magnesium oxide; potassium carbonate; periodic acid; XPhos;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: iron(III) chloride; periodic acid / acetonitrile / 20 - 30 °C
2: [bis(acetoxy)iodo]benzene; magnesium oxide; dirhodium(II) tetracarboxylate / dichloromethane / 16 h / 20 °C
3: potassium carbonate / methanol / 1 h / 20 °C
4: pyridine / 0 - 20 °C
5: hydrogenchloride; titanium(III) chloride / tetrahydrofuran / 18 h / 20 °C
6: chloro(2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct; XPhos; potassium phosphate / toluene; 1-methyl-pyrrolidin-2-one / 3 h / 130 °C / Inert atmosphere; Microwave irradiation
7: sodium ethanolate / ethanol / 73.5 h / 60 °C / Inert atmosphere
With
pyridine; hydrogenchloride; iron(III) chloride; potassium phosphate; titanium(III) chloride; dirhodium(II) tetracarboxylate; [bis(acetoxy)iodo]benzene; chloro(2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct; sodium ethanolate; magnesium oxide; potassium carbonate; periodic acid; XPhos;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; toluene; acetonitrile;
![(rac)-ethyl [(3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}benzyl)(methyl)oxido-λ<sup>6</sup>-sulfanylidene]carbamate](/Databaselist/images/loading.webp)
