(3R,5S,8R,9S,10S,13S,14S)-3-(Benzylamino-methyl)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one

Base Information

Chemical Name:(3R,5S,8R,9S,10S,13S,14S)-3-(Benzylamino-methyl)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one
CAS No.:210638-17-8
Molecular Formula:C₂₇H₃₉NO₂
Molecular Weight:409.612
Hs Code.:

Synonyms:(3R,5S,8R,9S,10S,13S,14S)-3-(Benzylamino-methyl)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one

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Chemical Property of (3R,5S,8R,9S,10S,13S,14S)-3-(Benzylamino-methyl)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one

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Technology Process of (3R,5S,8R,9S,10S,13S,14S)-3-(Benzylamino-methyl)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one

There total 6 articles about (3R,5S,8R,9S,10S,13S,14S)-3-(Benzylamino-methyl)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42153-87-7
spiro-3(R)-oxirane-5α-androstan-17-one

: 100-46-9
benzylamine

: 210638-17-8
(3R,5S,8R,9S,10S,13S,14S)-3-(Benzylamino-methyl)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one

Guidance literature:: With lithium perchlorate; In acetonitrile; at 55 ℃; for 168h;
DOI:10.1016/S0040-4039(98)00772-2

Reference yield:

: C₂₉H₄₃NO₃

: 210638-17-8
(3R,5S,8R,9S,10S,13S,14S)-3-(Benzylamino-methyl)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one

Guidance literature:: With hydrogenchloride; In acetone; at 20 ℃; for 2h;
DOI:10.1021/jm010286y

Reference yield:

: 481-29-8
Epiandrosterone

: 210638-17-8
(3R,5S,8R,9S,10S,13S,14S)-3-(Benzylamino-methyl)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: p-TSA / toluene / 24 h / Heating

2.1: 10.5 g / TPAP; NMO; molecular sieves / CH₂Cl₂ / 2 h

3.1: NaH / dimethylsulfoxide / 1 h / 20 °C

3.2: 6.5 g / dimethylsulfoxide; tetrahydrofuran

4.1: ethanol / 36 h / 60 °C

5.1: 3 N aq. HCl / acetone / 2 h / 20 °C

With hydrogenchloride; N-methyl-2-indolinone; molecular sieve; tetrapropylammonium perruthennate; sodium hydride; toluene-4-sulfonic acid; In ethanol; dichloromethane; dimethyl sulfoxide; acetone; toluene;
DOI:10.1021/jm010286y