(2-methoxyphenyl)({[4-methyl-1-(1,4,5,8-tetramethoxynaphthalen-2-yl)pent-3-en-1-yl]sulfanyl})methanone

Base Information

• Chemical Name: (2-methoxyphenyl)({[4-methyl-1-(1,4,5,8-tetramethoxynaphthalen-2-yl)pent-3-en-1-yl]sulfanyl})methanone
• CAS No.: 1055318-50-7
• Molecular Formula: C₂₈H₃₂O₆S
• Molecular Weight: 496.624
• Mol file: 1055318-50-7.mol

Synonyms:(2-methoxyphenyl)({[4-methyl-1-(1,4,5,8-tetramethoxynaphthalen-2-yl)pent-3-en-1-yl]sulfanyl})methanone

Chemical Property of (2-methoxyphenyl)({[4-methyl-1-(1,4,5,8-tetramethoxynaphthalen-2-yl)pent-3-en-1-yl]sulfanyl})methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-methoxyphenyl)({[4-methyl-1-(1,4,5,8-tetramethoxynaphthalen-2-yl)pent-3-en-1-yl]sulfanyl})methanone

There total 5 articles about (2-methoxyphenyl)({[4-methyl-1-(1,4,5,8-tetramethoxynaphthalen-2-yl)pent-3-en-1-yl]sulfanyl})methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(1,4,5,8-tetramethoxynaphthalen-7-yl)-4-methylpent-3-ene-1-thiol (1055318-38-1) + 2-Methoxybenzoic acid (579-75-9) → (2-methoxyphenyl)({[4-methyl-1-(1,4,5,8-tetramethoxynaphthalen-2-yl)pent-3-en-1-yl]sulfanyl})methanone (1055318-50-7)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.ejmech.2008.09.039

Reference yield: 87.0%

→ (2-methoxyphenyl)({[4-methyl-1-(1,4,5,8-tetramethoxynaphthalen-2-yl)pent-3-en-1-yl]sulfanyl})methanone (1055318-50-7)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield:

2-(1'-hydroxy-4'-methylpent-3'-en-1'-yl)-1,4,5,8-tetramethoxynaphthalene (171115-38-1) → (2-methoxyphenyl)({[4-methyl-1-(1,4,5,8-tetramethoxynaphthalen-2-yl)pent-3-en-1-yl]sulfanyl})methanone (1055318-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen bromide; thiourea / ethanol / 1 h / Inert atmosphere; Reflux

1.2: 2 h / Inert atmosphere; Reflux

2.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 24 h / 20 °C

With dmap; hydrogen bromide; thiourea; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1016/j.ejmech.2017.11.031

upstream raw materials:

1-(1,4,5,8-tetramethoxynaphthalen-7-yl)-4-methylpent-3-ene-1-thiol

2-Methoxybenzoic acid

2-(1'-hydroxy-4'-methylpent-3'-en-1'-yl)-1,4,5,8-tetramethoxynaphthalene

prenyl bromide

Downstream raw materials:

S-1-(1,4-dihydro-5,8-dimethoxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enyl 2-methoxybenzothioate

5,8-dimethoxy-6-[1-(2-methoxybenzoylsulfanyl)-4-methylpent-3-en-1-yl]-1,4-dihydronaphthalene-1,4-dione