(R)-N-[(1S,2S)-(2-hydroxy-1-methyl-2-phenylethyl)]-4-(4'-methoxybenzyloxy)-N,2-dimethylbutanamide

Base Information

Chemical Name:(R)-N-[(1S,2S)-(2-hydroxy-1-methyl-2-phenylethyl)]-4-(4'-methoxybenzyloxy)-N,2-dimethylbutanamide
CAS No.:1112335-58-6
Molecular Formula:C₂₃H₃₁NO₄
Molecular Weight:385.503
Hs Code.:

Synonyms:(R)-N-[(1S,2S)-(2-hydroxy-1-methyl-2-phenylethyl)]-4-(4'-methoxybenzyloxy)-N,2-dimethylbutanamide

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Chemical Property of (R)-N-[(1S,2S)-(2-hydroxy-1-methyl-2-phenylethyl)]-4-(4'-methoxybenzyloxy)-N,2-dimethylbutanamide

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Technology Process of (R)-N-[(1S,2S)-(2-hydroxy-1-methyl-2-phenylethyl)]-4-(4'-methoxybenzyloxy)-N,2-dimethylbutanamide

There total 1 articles about (R)-N-[(1S,2S)-(2-hydroxy-1-methyl-2-phenylethyl)]-4-(4'-methoxybenzyloxy)-N,2-dimethylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 159213-03-3
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide

: 447454-25-3
1-((2-iodoethoxy)methyl)-4-methoxybenzene

: 1112335-58-6
(R)-N-[(1S,2S)-(2-hydroxy-1-methyl-2-phenylethyl)]-4-(4'-methoxybenzyloxy)-N,2-dimethylbutanamide

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

1-((2-iodoethoxy)methyl)-4-methoxybenzene; In tetrahydrofuran; hexane; at 0 - 20 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol8029017

Reference yield: 85.0%

: 1112335-58-6
(R)-N-[(1S,2S)-(2-hydroxy-1-methyl-2-phenylethyl)]-4-(4'-methoxybenzyloxy)-N,2-dimethylbutanamide

: 727411-51-0
(R)-4-((4-methoxybenzyl)oxy)-2-methylbutan-1-ol

Guidance literature:: With n-butyllithium; borane-ammonia complex; diisopropylamine; In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol8029017