N-(3-((4,6-dimethoxy-2-morpholinopyrimidin-5-yl)thio)phenyl)acrylamide

Base Information

Chemical Name:N-(3-((4,6-dimethoxy-2-morpholinopyrimidin-5-yl)thio)phenyl)acrylamide
CAS No.:1268274-89-0
Molecular Formula:C₁₉H₂₂N₄O₄S
Molecular Weight:402.474
Hs Code.:

Synonyms:N-(3-((4,6-dimethoxy-2-morpholinopyrimidin-5-yl)thio)phenyl)acrylamide

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Chemical Property of N-(3-((4,6-dimethoxy-2-morpholinopyrimidin-5-yl)thio)phenyl)acrylamide

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Technology Process of N-(3-((4,6-dimethoxy-2-morpholinopyrimidin-5-yl)thio)phenyl)acrylamide

There total 4 articles about N-(3-((4,6-dimethoxy-2-morpholinopyrimidin-5-yl)thio)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1268274-88-9
3-((4,6-dimethoxy-2-morpholinopyrimidin-5-yl)thio)aniline

: 814-68-6,25189-84-8
acryloyl chloride

: 1268274-89-0
N-(3-((4,6-dimethoxy-2-morpholinopyrimidin-5-yl)thio)phenyl)acrylamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm401551n

Reference yield:

: 13223-25-1
2-chloro-4,6-dimethoxypyrimidine

: 1268274-89-0
N-(3-((4,6-dimethoxy-2-morpholinopyrimidin-5-yl)thio)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 2.5 h / 90 °C / Inert atmosphere

2: N-iodo-succinimide / acetonitrile / 2 h / 20 °C / Inert atmosphere

3: 2.9-dimethyl-1,10-phenanthroline; copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 120 °C / Inert atmosphere

4: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With N-iodo-succinimide; copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm401551n

Reference yield:

: 1568909-08-9
4-(5-iodo-4,6-dimethoxypyrimidin-2-yl)morpholine

: 1268274-89-0
N-(3-((4,6-dimethoxy-2-morpholinopyrimidin-5-yl)thio)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2.9-dimethyl-1,10-phenanthroline; copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 120 °C / Inert atmosphere

2: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm401551n