(E)-17-[N-(2-(tert-Butyloxycarbonylamino)ethyl)]-N-[N⁴-(benzyloxycarbonyl)cytosine-1-ylacetyl]glycinyloxy-4,7,10,13-tetraoxa-15-heptadecenoic acic

Base Information

• Chemical Name: (E)-17-[N-(2-(tert-Butyloxycarbonylamino)ethyl)]-N-[N⁴-(benzyloxycarbonyl)cytosine-1-ylacetyl]glycinyloxy-4,7,10,13-tetraoxa-15-heptadecenoic acic
• CAS No.: 230617-99-9
• Molecular Formula: C₃₆H₅₁N₅O₁₄
• Molecular Weight: 777.826

Synonyms:(E)-17-[N-(2-(tert-Butyloxycarbonylamino)ethyl)]-N-[N⁴-(benzyloxycarbonyl)cytosine-1-ylacetyl]glycinyloxy-4,7,10,13-tetraoxa-15-heptadecenoic acic

Chemical Property of (E)-17-[N-(2-(tert-Butyloxycarbonylamino)ethyl)]-N-[N⁴-(benzyloxycarbonyl)cytosine-1-ylacetyl]glycinyloxy-4,7,10,13-tetraoxa-15-heptadecenoic acic

Chemical Property:

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Technology Process of (E)-17-[N-(2-(tert-Butyloxycarbonylamino)ethyl)]-N-[N⁴-(benzyloxycarbonyl)cytosine-1-ylacetyl]glycinyloxy-4,7,10,13-tetraoxa-15-heptadecenoic acic

There total 4 articles about (E)-17-[N-(2-(tert-Butyloxycarbonylamino)ethyl)]-N-[N⁴-(benzyloxycarbonyl)cytosine-1-ylacetyl]glycinyloxy-4,7,10,13-tetraoxa-15-heptadecenoic acic which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(E)-17-[N-(2-(tert-Butyloxycarbonylamino)ethyl)]-N-[N4-(benzyloxycarbonyl)cytosine-1-ylacetyl]glycinyloxy-4,7,10,13-tetraoxa-15-heptadecenoic acid phenacyl ester → (E)-17-[N-(2-(tert-Butyloxycarbonylamino)ethyl)]-N-[N4-(benzyloxycarbonyl)cytosine-1-ylacetyl]glycinyloxy-4,7,10,13-tetraoxa-15-heptadecenoic acic (230617-99-9)

Guidance literature:

With acetic acid; zinc; for 1.5h;

DOI:10.1002/1521-3765(20010917)7:18<3911::AID-CHEM3911>3.0.CO;2-1

Reference yield:

N-((N-4-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine (144564-94-3) → (E)-17-[N-(2-(tert-Butyloxycarbonylamino)ethyl)]-N-[N4-(benzyloxycarbonyl)cytosine-1-ylacetyl]glycinyloxy-4,7,10,13-tetraoxa-15-heptadecenoic acic (230617-99-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / Bu₄NBr; aq. NaHCO₃ / CH₂Cl₂ / 14 h

2: 79 percent / Zn; AcOH / 1.5 h

With tetrabutylammomium bromide; sodium hydrogencarbonate; acetic acid; zinc; In dichloromethane;

DOI:10.1002/1521-3765(20010917)7:18<3911::AID-CHEM3911>3.0.CO;2-1

Reference yield:

(E)-17-bromo-4,7,10,13-tetraoxa-15-heptadecenoic acid phenacyl ester (186021-07-8) → (E)-17-[N-(2-(tert-Butyloxycarbonylamino)ethyl)]-N-[N4-(benzyloxycarbonyl)cytosine-1-ylacetyl]glycinyloxy-4,7,10,13-tetraoxa-15-heptadecenoic acic (230617-99-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / Bu₄NBr; aq. NaHCO₃ / CH₂Cl₂ / 14 h

2: 79 percent / Zn; AcOH / 1.5 h

With tetrabutylammomium bromide; sodium hydrogencarbonate; acetic acid; zinc; In dichloromethane;

DOI:10.1002/1521-3765(20010917)7:18<3911::AID-CHEM3911>3.0.CO;2-1

upstream raw materials:

N-((N-⁴-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine

(E)-17-bromo-4,7,10,13-tetraoxa-15-heptadecenoic acid phenacyl ester

Downstream raw materials:

C₆₃H₇₀N₂₀O₁₉

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