4-(N-[2,4-DIAMINO-6-PTERIDINYLMETHYL]-AMINO)BENZOIC ACID SODIUM SALT

Base Information

• Chemical Name: 4-(N-[2,4-DIAMINO-6-PTERIDINYLMETHYL]-AMINO)BENZOIC ACID SODIUM SALT
• CAS No.: 36093-85-3
• Molecular Formula: C14H13 N7 O2
• Molecular Weight: 311.303
• Hs Code.: 2933990090
• Mol file: 36093-85-3.mol

Synonyms:4-Amino-4-deoxopteroicacid; 4-Aminodeoxopteroic acid

Chemical Property of 4-(N-[2,4-DIAMINO-6-PTERIDINYLMETHYL]-AMINO)BENZOIC ACID SODIUM SALT

Chemical Property:

• Vapor Pressure: 1.6E-19mmHg at 25°C
• Boiling Point: 681.8°C at 760 mmHg
• Flash Point: 366.1°C
• PSA: 152.93000
• Density: 1.607g/cm³
• LogP: 2.12990
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly, Heated), Methaol (Slightly)

Purity/Quality:

99.90% ^*data from raw suppliers

4-AminodeoxopteroicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(N-[2,4-DIAMINO-6-PTERIDINYLMETHYL]-AMINO)BENZOIC ACID SODIUM SALT is an intermediate for the synthesis of Aminopterin (A628850), a folic acid antagonist. They can also be used as precursors for De Novo synthesis of antifolates: A novel class of antimalarials.

Technology Process of 4-(N-[2,4-DIAMINO-6-PTERIDINYLMETHYL]-AMINO)BENZOIC ACID SODIUM SALT

There total 12 articles about 4-(N-[2,4-DIAMINO-6-PTERIDINYLMETHYL]-AMINO)BENZOIC ACID SODIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,4-diamino-5,6,7,8-tetrahydro-6-hydroxymethylpteridine (89852-78-8) + 4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 4-amino>benzoic acid (36093-85-3)

Guidance literature:

With bromine; triphenylphosphine; In ISOPROPYLAMIDE; at 8 ℃; for 0.75h;

2,4-diamino-5,6,7,8-tetrahydro-6-hydroxymethylpteridine; In ISOPROPYLAMIDE; at 20 ℃; for 18h;

4-amino-benzoic acid; With barium(II) oxide; In ISOPROPYLAMIDE; at 53 - 57 ℃; for 22 - 26h;

Reference yield: 95.0%

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) + pteridin-6-yl-methanol (46046-65-5) → 4-amino>benzoic acid (36093-85-3)

Guidance literature:

In methanol; dichloromethane; water;

Reference yield: 86.0%

aminopterin (54-62-6,64801-55-4) → 4-amino>benzoic acid (36093-85-3)

Guidance literature:

With sodium hydroxide; sodium acetate; acetic acid; zinc(II) chloride; at 37 ℃; for 24h; carboxypeptidase G₁;

DOI:10.1021/jm00371a008

upstream raw materials:

4-[3-(2,6-Diamino-5-nitro-pyrimidin-4-ylamino)-2-oxo-propylamino]-benzoic acid

4-amino-benzoic acid

6-bromomethyl-2,4-diaminopteridine hydrobromide

aminopterin

Downstream raw materials:

3,5-Dichloro-4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]-benzoic acid

N^α-(4-amino-4-deoxy-10-formylpteroyl)-N^δ-Boc-L-ornithinyl-L-phenylalanine tert-butyl ester

sodium salt of 4-amino-4-deoxypteroic acid

C₃₁H₃₇N₁₁O₆S₂