(ethoxycarbonyl-4 methoxycarbonyl-5 dihydro-3,6 2H-thiazine-1,3 yl-2)-2 methyl-2 propanoate de p-methoxybenzyle

Base Information

• Chemical Name: (ethoxycarbonyl-4 methoxycarbonyl-5 dihydro-3,6 2H-thiazine-1,3 yl-2)-2 methyl-2 propanoate de p-methoxybenzyle
• CAS No.: 115823-91-1
• Molecular Formula: C₂₁H₂₇NO₇S
• Molecular Weight: 437.514
• Mol file: 115823-91-1.mol

Synonyms:(ethoxycarbonyl-4 methoxycarbonyl-5 dihydro-3,6 2H-thiazine-1,3 yl-2)-2 methyl-2 propanoate de p-methoxybenzyle

Chemical Property of (ethoxycarbonyl-4 methoxycarbonyl-5 dihydro-3,6 2H-thiazine-1,3 yl-2)-2 methyl-2 propanoate de p-methoxybenzyle

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (ethoxycarbonyl-4 methoxycarbonyl-5 dihydro-3,6 2H-thiazine-1,3 yl-2)-2 methyl-2 propanoate de p-methoxybenzyle

There total 5 articles about (ethoxycarbonyl-4 methoxycarbonyl-5 dihydro-3,6 2H-thiazine-1,3 yl-2)-2 methyl-2 propanoate de p-methoxybenzyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(ethoxycarbonyl-4 methoxycarbonyl-5 6H-thiazine-1,3 yl-2)-2 methyl-2 propanoate de p-methoxybenzyle (115823-89-7) → (ethoxycarbonyl-4 methoxycarbonyl-5 dihydro-3,6 2H-thiazine-1,3 yl-2)-2 methyl-2 propanoate de p-methoxybenzyle (115823-91-1)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; In methanol; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85890-7

Reference yield:

cyano-2 methyl propanoate de p-methoxybenzyle (115849-39-3) → (ethoxycarbonyl-4 methoxycarbonyl-5 dihydro-3,6 2H-thiazine-1,3 yl-2)-2 methyl-2 propanoate de p-methoxybenzyle (115823-91-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent / 1.) H₂S; 2.) Et₃N / pyridine / 24 h

2: 74 percent / CHCl₃ / 24 h / Heating

3: 87 percent / amberlyst 15 / CH₂Cl₂ / 20 h / Ambient temperature

4: 82 percent / acetic acid, sodium cyanide, MnO₂ / 1.25 h / Ambient temperature

5: 94 percent / NaBH₃CN, 2 N HCl / methanol / 1 h / Ambient temperature

With hydrogenchloride; sodium cyanide; manganese(IV) oxide; Amberlyst 15; hydrogen sulfide; sodium cyanoborohydride; acetic acid; triethylamine; In pyridine; methanol; dichloromethane; chloroform;

DOI:10.1016/S0040-4020(01)85890-7

Reference yield:

methyl-2 thiocarbamoyl-2 propanoate de p-methoxybenzyle (115823-83-1) → (ethoxycarbonyl-4 methoxycarbonyl-5 dihydro-3,6 2H-thiazine-1,3 yl-2)-2 methyl-2 propanoate de p-methoxybenzyle (115823-91-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 74 percent / CHCl₃ / 24 h / Heating

2: 87 percent / amberlyst 15 / CH₂Cl₂ / 20 h / Ambient temperature

3: 82 percent / acetic acid, sodium cyanide, MnO₂ / 1.25 h / Ambient temperature

4: 94 percent / NaBH₃CN, 2 N HCl / methanol / 1 h / Ambient temperature

With hydrogenchloride; sodium cyanide; manganese(IV) oxide; Amberlyst 15; sodium cyanoborohydride; acetic acid; In methanol; dichloromethane; chloroform;

DOI:10.1016/S0040-4020(01)85890-7

upstream raw materials:

(ethoxycarbonyl-4 methoxycarbonyl-5 6H-thiazine-1,3 yl-2)-2 methyl-2 propanoate de p-methoxybenzyle

cyano-2 methyl propanoate de p-methoxybenzyle

methyl-2 thiocarbamoyl-2 propanoate de p-methoxybenzyle

(ethoxycarbonyl-4 formyl-5 6H-thiazine-1,3 yl-2)-2 methyl-2 propanoate de p-methoxybenzyle