(4S)-4,5-dihydro-2-(4′-(trifluoromethyl)-2′-bromophenyl)-4-isopropyloxazole

Base Information

Chemical Name:(4S)-4,5-dihydro-2-(4′-(trifluoromethyl)-2′-bromophenyl)-4-isopropyloxazole
CAS No.:1400638-86-9
Molecular Formula:C₁₃H₁₃BrF₃NO
Molecular Weight:336.152
Hs Code.:

Synonyms:(4S)-4,5-dihydro-2-(4′-(trifluoromethyl)-2′-bromophenyl)-4-isopropyloxazole

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Chemical Property of (4S)-4,5-dihydro-2-(4′-(trifluoromethyl)-2′-bromophenyl)-4-isopropyloxazole

Chemical Property:

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Technology Process of (4S)-4,5-dihydro-2-(4′-(trifluoromethyl)-2′-bromophenyl)-4-isopropyloxazole

There total 3 articles about (4S)-4,5-dihydro-2-(4′-(trifluoromethyl)-2′-bromophenyl)-4-isopropyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 328-89-2
2-bromo-4-trifluoromethyl-benzoic acid

: 1400638-86-9
(4S)-4,5-dihydro-2-(4′-(trifluoromethyl)-2′-bromophenyl)-4-isopropyloxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: toluene-4-sulfonic acid; triethylamine / dichloromethane / 23 h / Inert atmosphere; Reflux

With 2-chloro-1-methyl-pyridinium iodide; toluene-4-sulfonic acid; triethylamine; In dichloromethane;
DOI:10.1021/om3007163

Reference yield:

: C₁₃H₁₅BrF₃NO₂

: 1400638-86-9
(4S)-4,5-dihydro-2-(4′-(trifluoromethyl)-2′-bromophenyl)-4-isopropyloxazole

Guidance literature:: With toluene-4-sulfonic acid; triethylamine; In dichloromethane; for 23h; Inert atmosphere; Reflux;
DOI:10.1021/om3007163

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 1400638-86-9
(4S)-4,5-dihydro-2-(4′-(trifluoromethyl)-2′-bromophenyl)-4-isopropyloxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: toluene-4-sulfonic acid; triethylamine / dichloromethane / 23 h / Inert atmosphere; Reflux

With 2-chloro-1-methyl-pyridinium iodide; toluene-4-sulfonic acid; triethylamine; In dichloromethane;
DOI:10.1021/om3007163