(2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}butyrolactone

Base Information

Chemical Name:(2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}butyrolactone
CAS No.:902468-35-3
Molecular Formula:C₁₄H₂₃NO₆
Molecular Weight:301.34
Hs Code.:

Synonyms:(2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}butyrolactone

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Chemical Property of (2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}butyrolactone

Chemical Property:

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Technology Process of (2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}butyrolactone

There total 1 articles about (2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}butyrolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 40856-59-5,132957-40-5
tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate

: 902468-35-3
(2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}butyrolactone

Guidance literature:: With dmap; In acetonitrile; at 20 ℃; for 15h;
DOI:10.1002/chem.200501128

Reference yield:

: 902468-35-3
(2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}butyrolactone

: C₃₂H₄₈N₂O₇Si

Guidance literature:: Multi-step reaction with 6 steps

1.1: aq. CsOH / methanol / 2 h / 20 °C

1.2: 79 percent / dimethylformamide / 18 h / 20 °C

2.1: DMSO; oxalyl chloride; NEtiPr₂ / CH₂Cl₂ / -60 - 20 °C

3.1: CH₂Cl₂ / 20 h / 20 °C

4.1: 11.68 g / ammonium fluoride / methanol / 0.08 h

5.1: 90 percent / imidazole / dimethylformamide / 15 h / 20 °C

6.1: H₂ / Pd/C / methanol; acetic acid / 15 h / 20 °C

With 1H-imidazole; cesium hydroxide; ammonium fluoride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; 2.1: Swern oxidation;
DOI:10.1002/chem.200501128

Reference yield:

: 902468-35-3
(2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}butyrolactone

: 902468-38-6
(3S)-[bis(tert-butyloxycarbonyl)amino]-5-(tert-butyldiphenylsilanyloxy)-piperidine-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: aq. CsOH / methanol / 2 h / 20 °C

1.2: 79 percent / dimethylformamide / 18 h / 20 °C

2.1: DMSO; oxalyl chloride; NEtiPr₂ / CH₂Cl₂ / -60 - 20 °C

3.1: CH₂Cl₂ / 20 h / 20 °C

4.1: 11.68 g / ammonium fluoride / methanol / 0.08 h

5.1: 90 percent / imidazole / dimethylformamide / 15 h / 20 °C

6.1: H₂ / Pd/C / methanol; acetic acid / 15 h / 20 °C

7.1: 4.022 g / N,N-dimethylaminopyridine / toluene / 42 h / Heating

With 1H-imidazole; dmap; cesium hydroxide; ammonium fluoride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene; 2.1: Swern oxidation;
DOI:10.1002/chem.200501128