(S)-3-(1-amino-2-phenylethyl)-4H-[1,2,4]oxadiazol-5-one hydrochloride

Base Information

Chemical Name:(S)-3-(1-amino-2-phenylethyl)-4H-[1,2,4]oxadiazol-5-one hydrochloride
CAS No.:1198320-42-1
Molecular Formula:C₁₀H₁₁N₃O₂*ClH
Molecular Weight:241.677
Hs Code.:

Synonyms:(S)-3-(1-amino-2-phenylethyl)-4H-[1,2,4]oxadiazol-5-one hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(1-amino-2-phenylethyl)-4H-[1,2,4]oxadiazol-5-one hydrochloride

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Technology Process of (S)-3-(1-amino-2-phenylethyl)-4H-[1,2,4]oxadiazol-5-one hydrochloride

There total 1 articles about (S)-3-(1-amino-2-phenylethyl)-4H-[1,2,4]oxadiazol-5-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1198320-38-5
(S)-[1-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

: 1198320-42-1
(S)-3-(1-amino-2-phenylethyl)-4H-[1,2,4]oxadiazol-5-one hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; for 18h; Inert atmosphere;
DOI:10.1016/j.tet.2009.09.045

Reference yield: 93.0%

: 1198320-42-1
(S)-3-(1-amino-2-phenylethyl)-4H-[1,2,4]oxadiazol-5-one hydrochloride

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 1198320-47-6
(R)-3,3,3-trifluoro-2-methoxy-N-(S)-[1-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-2-phenylethyl]-2-phenyl-propionamide

Guidance literature:: (S)-3-(1-amino-2-phenylethyl)-4H-[1,2,4]oxadiazol-5-one hydrochloride; (R)-methoxytrifluoromethylphenylacetyl chloride; With sodium carbonate; In tetrahydrofuran; water; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate; optical yield given as %ee;
DOI:10.1016/j.tet.2009.09.045

Reference yield: 84.0%

: 15761-38-3
L-N-Boc-Ala

: 1198320-42-1
(S)-3-(1-amino-2-phenylethyl)-4H-[1,2,4]oxadiazol-5-one hydrochloride

: 1198320-52-3
{1-[1-(5-oxo-4,5-dihydro[1,2,4]oxadiazol-3-yl)-2-phenylethylcarbamoyl]ethyl}carbamic acid tert-butyl ester

Guidance literature:: L-N-Boc-Ala; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

(S)-3-(1-amino-2-phenylethyl)-4H-[1,2,4]oxadiazol-5-one hydrochloride; With 4-methyl-morpholine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2009.09.045