(R)-tert-butyl 3-benzyl-3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-oxoindoline-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 3-benzyl-3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-oxoindoline-1-carboxylate
CAS No.:1043872-76-9
Molecular Formula:C₃₂H₃₆N₂O₅
Molecular Weight:528.648
Hs Code.:

Synonyms:(R)-tert-butyl 3-benzyl-3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-oxoindoline-1-carboxylate

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Chemical Property of (R)-tert-butyl 3-benzyl-3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-oxoindoline-1-carboxylate

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Technology Process of (R)-tert-butyl 3-benzyl-3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-oxoindoline-1-carboxylate

There total 3 articles about (R)-tert-butyl 3-benzyl-3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-oxoindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 862907-10-6
tert-butyl 3-benzyl-2-oxoindoline-1-carboxylate

: 150884-50-7
benzaldehyde N-boc imine

: 1043872-76-9
(R)-tert-butyl 3-benzyl-3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-oxoindoline-1-carboxylate

: 1043872-77-0
C₃₂H₃₆N₂O₅

Guidance literature:: With C₂₄H₂₄F₃N₃S; In m-xylene; at 5 - 10 ℃; for 10h; optical yield given as %ee; enantioselective reaction; Molecular sieve;
DOI:10.1021/ol801351j

Reference yield: 81.0%

: 862907-10-6
tert-butyl 3-benzyl-2-oxoindoline-1-carboxylate

: 150884-50-7
benzaldehyde N-boc imine

: 1043872-76-9
(R)-tert-butyl 3-benzyl-3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-oxoindoline-1-carboxylate

: C₃₂H₃₆N₂O₅

Guidance literature:: With 2,6-bis((4S,5S)-4-(methoxymethyl)-5-phenyl-4,5-dihydrooxazol-2-yl)pyridine; triethylamine; calcium iodide; In dichloromethane; at -78 ℃; for 18h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/acs.orglett.5b00749

Reference yield: 10.0%

: 862907-10-6
tert-butyl 3-benzyl-2-oxoindoline-1-carboxylate

: 150884-50-7
benzaldehyde N-boc imine

: 1043872-76-9
(R)-tert-butyl 3-benzyl-3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-oxoindoline-1-carboxylate

: 1043872-77-0
C₃₂H₃₆N₂O₅

: C₃₂H₃₆N₂O₅

Guidance literature:: With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methyl)thiourea; In m-xylene; at 5 - 10 ℃; for 10h; optical yield given as %ee; enantioselective reaction; Molecular sieve;
DOI:10.1021/ol801351j