4-Chloro-3-methyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride

Base Information

Chemical Name:4-Chloro-3-methyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride
CAS No.:851520-86-0
Molecular Formula:C₁₁H₁₁Cl₂N₃O
Molecular Weight:272.134
Hs Code.:
DSSTox Substance ID:DTXSID701147383

Synonyms:DTXSID701147383;4-Chloro-3-methyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride;851520-86-0

Suppliers and Price of 4-Chloro-3-methyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Chloro-3-methyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:271.0279174
Heavy Atom Count:17
Complexity:302

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCCN1C2=NC=C(C(=C2C(=N1)C)Cl)C(=O)Cl

Technology Process of 4-Chloro-3-methyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride

There total 4 articles about 4-Chloro-3-methyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1027557-32-9
4-chloro-3-methyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

: 851520-86-0
4-chloro-3-methyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride

Guidance literature:: With thionyl chloride; In toluene; for 2h; Reflux;

Reference yield:

: 37801-49-3
ethyl 4-chloro-3-methyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

: 851520-86-0
4-chloro-3-methyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: aq. KOH / 1,2-dimethoxy-ethane / 20 °C

2: SOCl₂ / 80 °C

With potassium hydroxide; thionyl chloride; In 1,2-dimethoxyethane;
DOI:10.1248/cpb.52.1098

Reference yield:

: 3524-34-3
3-methyl-1-propyl-1H-pyrazol-5-amine

: 851520-86-0
4-chloro-3-methyl-1-propyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1: 120 °C

2: POCl₃ / 120 °C

3: aq. KOH / 1,2-dimethoxy-ethane / 20 °C

4: SOCl₂ / 80 °C

With potassium hydroxide; thionyl chloride; trichlorophosphate; In 1,2-dimethoxyethane; 1: Michael addition;
DOI:10.1248/cpb.52.1098