ethyl 5,6-dihydro-3-(o-fluorophenyl)-8-methoxyfuro<3,2-f>-1,2-benzisoxazole-6-carboxylate

Base Information

Chemical Name:ethyl 5,6-dihydro-3-(o-fluorophenyl)-8-methoxyfuro<3,2-f>-1,2-benzisoxazole-6-carboxylate
CAS No.:90247-02-2
Molecular Formula:C₁₉H₁₆FNO₅
Molecular Weight:357.338
Hs Code.:

Synonyms:ethyl 5,6-dihydro-3-(o-fluorophenyl)-8-methoxyfuro<3,2-f>-1,2-benzisoxazole-6-carboxylate

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Chemical Property of ethyl 5,6-dihydro-3-(o-fluorophenyl)-8-methoxyfuro<3,2-f>-1,2-benzisoxazole-6-carboxylate

Chemical Property:

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Technology Process of ethyl 5,6-dihydro-3-(o-fluorophenyl)-8-methoxyfuro<3,2-f>-1,2-benzisoxazole-6-carboxylate

There total 8 articles about ethyl 5,6-dihydro-3-(o-fluorophenyl)-8-methoxyfuro<3,2-f>-1,2-benzisoxazole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₀FNO₇

: 90247-02-2
ethyl 5,6-dihydro-3-(o-fluorophenyl)-8-methoxyfuro<3,2-f>-1,2-benzisoxazole-6-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 4h; Yield given; Ambient temperature;
DOI:10.1021/jm00374a014

Reference yield:

: 19283-70-6
3,4-dimethoxysalicylaldehyde

: 90247-02-2
ethyl 5,6-dihydro-3-(o-fluorophenyl)-8-methoxyfuro<3,2-f>-1,2-benzisoxazole-6-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: K₂CO₃ / butan-2-one / 4 h / Heating

2: ethanolic KOH

3: aq. NaOH, 5percent sodium amalgam / 5 h

4: H₂SO₄ / Ambient temperature

5: 32 percent / AlCl₃ / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C

6: 18 percent / NH₂OH*HCl, pyridine / 4 h / Heating

7: 1 h / 90 °C

8: NaH / dimethylformamide / 4 h / Ambient temperature

With pyridine; potassium hydroxide; sodium hydroxide; sodium amalgam; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; sodium hydride; potassium carbonate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00374a014

Reference yield:

: 76313-60-5
6,7-dimethoxybenzofuran-2-carboxylic acid

: 90247-02-2
ethyl 5,6-dihydro-3-(o-fluorophenyl)-8-methoxyfuro<3,2-f>-1,2-benzisoxazole-6-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: aq. NaOH, 5percent sodium amalgam / 5 h

2: H₂SO₄ / Ambient temperature

3: 32 percent / AlCl₃ / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C

4: 18 percent / NH₂OH*HCl, pyridine / 4 h / Heating

5: 1 h / 90 °C

6: NaH / dimethylformamide / 4 h / Ambient temperature

With pyridine; sodium hydroxide; sodium amalgam; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; sodium hydride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00374a014