2-((Z)-3-((phenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide

Base Information

Chemical Name:2-((Z)-3-((phenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide
CAS No.:1290088-96-8
Molecular Formula:C₃₄H₃₃N₃O₂
Molecular Weight:515.655
Hs Code.:

Synonyms:2-((Z)-3-((phenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((Z)-3-((phenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide

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Technology Process of 2-((Z)-3-((phenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide

There total 5 articles about 2-((Z)-3-((phenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1332647-15-0
C₂₈H₂₇IN₂O₂

: 62-53-3
aniline

: 1290088-96-8
2-((Z)-3-((phenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; for 7h; stereoselective reaction; Reflux;
DOI:10.1016/j.tet.2011.02.005

Reference yield:

: 615-43-0
2-iodophenylamine

: 1290088-96-8
2-((Z)-3-((phenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 0.5 h / 20 °C

1.2: 0.25 h / 20 °C

1.3: 24 h / 20 °C

2.1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 7 h / Reflux

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In methanol; toluene; 1.1: Ugi condensation / 1.2: Ugi condensation / 1.3: Ugi condensation / 2.1: domino Heck-Buchwald reaction;
DOI:10.1016/j.tet.2011.02.005

Reference yield:

: 88333-03-3,10340-91-7
Benzyl isocyanide

: 1290088-96-8
2-((Z)-3-((phenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 0.5 h / 20 °C

1.2: 0.25 h / 20 °C

1.3: 24 h / 20 °C

2.1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 7 h / Reflux

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In methanol; toluene; 1.1: Ugi condensation / 1.2: Ugi condensation / 1.3: Ugi condensation / 2.1: domino Heck-Buchwald reaction;
DOI:10.1016/j.tet.2011.02.005