Technology Process of 1-phenethyl-1,3-dihydroisobenzofuran
There total 4 articles about 1-phenethyl-1,3-dihydroisobenzofuran which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
manganese(IV) oxide; 1,10-Phenanthroline; copper(II) bis(trifluoromethanesulfonate);
In
1,2-dichloro-ethane;
at 105 ℃;
for 24h;
Molecular sieve;
Sealed tube;
Inert atmosphere;
DOI:10.1039/c9sc02835h
- Guidance literature:
-
Multi-step reaction with 3 steps
1: methanol; water / 0 - 20 °C
2: potassium hydride / tetrahydrofuran / 50 °C
3: cesiumhydroxide monohydrate; cyclopentyl methyl ether; [2′-(amino-κN)[1,1′-biphenyl]-2-yl-κC][butylbis(tricyclo-[3.3.1.13,7]dec-1-yl)phosphine]chloropalladium / 24 h / 105 °C / Sealed tube
With
cesiumhydroxide monohydrate; cyclopentyl methyl ether; [2′-(amino-κN)[1,1′-biphenyl]-2-yl-κC][butylbis(tricyclo-[3.3.1.13,7]dec-1-yl)phosphine]chloropalladium; potassium hydride;
In
tetrahydrofuran; methanol; water;
DOI:10.1021/ja307861n
- Guidance literature:
-
Multi-step reaction with 4 steps
1: [1,3-bis(cyclohexyl)imidazol-2-ylidene]copper(I) chloride; sodium t-butanolate / toluene / 1.5 h / 20 °C / Inert atmosphere
2: methanol; water / 0 - 20 °C
3: potassium hydride / tetrahydrofuran / 50 °C
4: cesiumhydroxide monohydrate; cyclopentyl methyl ether; [2′-(amino-κN)[1,1′-biphenyl]-2-yl-κC][butylbis(tricyclo-[3.3.1.13,7]dec-1-yl)phosphine]chloropalladium / 24 h / 105 °C / Sealed tube
With
cesiumhydroxide monohydrate; cyclopentyl methyl ether; [1,3-bis(cyclohexyl)imidazol-2-ylidene]copper(I) chloride; [2′-(amino-κN)[1,1′-biphenyl]-2-yl-κC][butylbis(tricyclo-[3.3.1.13,7]dec-1-yl)phosphine]chloropalladium; potassium hydride; sodium t-butanolate;
In
tetrahydrofuran; methanol; water; toluene;
DOI:10.1021/ja307861n
