N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl)-3-(trifluoromethyl)-phenyl)-2,4-dichlorobenzamide

Base Information

• Chemical Name: N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl)-3-(trifluoromethyl)-phenyl)-2,4-dichlorobenzamide
• CAS No.: 1312711-33-3
• Molecular Formula: C₂₉H₂₅Cl₂F₅N₆O₂
• Molecular Weight: 655.455
• Mol file: 1312711-33-3.mol

Synonyms:N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl)-3-(trifluoromethyl)-phenyl)-2,4-dichlorobenzamide

Chemical Property of N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl)-3-(trifluoromethyl)-phenyl)-2,4-dichlorobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl)-3-(trifluoromethyl)-phenyl)-2,4-dichlorobenzamide

There total 5 articles about N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl)-3-(trifluoromethyl)-phenyl)-2,4-dichlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,4 dichlorobenzoic acid (50-84-0) + 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[4-(4-amino-2-(trifluoromethyl)phenyl)piperazin-1-yl]-propan-2-ol (1312711-11-7) → N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl)-3-(trifluoromethyl)-phenyl)-2,4-dichlorobenzamide (1312711-33-3)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2011.04.022

Reference yield:

1-[4-nitro-2-(trifluoromethyl)phenyl]piperazine (381242-61-1) → N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl)-3-(trifluoromethyl)-phenyl)-2,4-dichlorobenzamide (1312711-33-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / ethanol / 5 h / 70 - 80 °C

2: hydrazine hydrate / ethanol / 3 h / 70 - 80 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With dmap; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/j.ejmech.2011.04.022

Reference yield:

4-chloro-3-(trifluoromethyl)nitrobenzene (777-37-7) → N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl)-3-(trifluoromethyl)-phenyl)-2,4-dichlorobenzamide (1312711-33-3)

Guidance literature:

Multi-step reaction with 4 steps

1: acetonitrile / 10 h / Reflux

2: triethylamine / ethanol / 5 h / 70 - 80 °C

3: hydrazine hydrate / ethanol / 3 h / 70 - 80 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With dmap; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane; acetonitrile;

DOI:10.1016/j.ejmech.2011.04.022

upstream raw materials:

1-[4-nitro-2-(trifluoromethyl)phenyl]piperazine

1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[4-(2-trifluoromethyl-4-nitro-phenyl)-piperazin-1-yl]-propan-2-ol

2,4 dichlorobenzoic acid

1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[4-(4-amino-2-(trifluoromethyl)phenyl)piperazin-1-yl]-propan-2-ol