6-[bis(carboxymethyl)amino]-6-[(1R,4R)-4-[(didecylamino)-carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H) diacetic acid

Base Information

Chemical Name:6-[bis(carboxymethyl)amino]-6-[(1R,4R)-4-[(didecylamino)-carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H) diacetic acid
CAS No.:1456626-25-7
Molecular Formula:C₄₀H₇₂N₄O₉
Molecular Weight:753.033
Hs Code.:

Synonyms:6-[bis(carboxymethyl)amino]-6-[(1R,4R)-4-[(didecylamino)-carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H) diacetic acid

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Chemical Property of 6-[bis(carboxymethyl)amino]-6-[(1R,4R)-4-[(didecylamino)-carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H) diacetic acid

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Technology Process of 6-[bis(carboxymethyl)amino]-6-[(1R,4R)-4-[(didecylamino)-carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H) diacetic acid

There total 12 articles about 6-[bis(carboxymethyl)amino]-6-[(1R,4R)-4-[(didecylamino)-carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H) diacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1456626-22-4
6-[bis[2-[(1,1-dimethyl)ethoxy]-2-oxoethyl]amino]-6-[(1R,4R)-4-[(didecylamino)carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis[(1,1-dimethyl)ethyl] ester

: 1456626-25-7
6-[bis(carboxymethyl)amino]-6-[(1R,4R)-4-[(didecylamino)-carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H) diacetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1112178-70-7
(1R,4R)-4-[(methylsulfonyloxy)methyl]cyclohexanecarboxylic acid methyl ester

: 1456626-25-7
6-[bis(carboxymethyl)amino]-6-[(1R,4R)-4-[(didecylamino)-carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H) diacetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium iodide / acetone; diethyl ether / 72.5 h / 20 °C / Reflux

2.1: sodium nitrite; 3,5-dihydroxyphenol / dimethyl sulfoxide / 48 h / 20 °C / Inert atmosphere

3.1: ethanol / 1.5 h / 60 - 80 °C

3.2: 6 h / 80 °C

4.1: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran; methanol / 11 h / 40 °C

5.1: potassium carbonate; sodium sulfate / acetonitrile; ethyl acetate / 1 h / 80 °C

6.1: water; sodium hydroxide / isopropyl alcohol / 5.5 h / 20 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 49 h / 0 - 20 °C

8.1: N-ethyl-N,N-diisopropylamine / chloroform / 20 °C

9.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With 3,5-dihydroxyphenol; 5%-palladium/activated carbon; water; hydrogen; potassium carbonate; sodium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; chloroform; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol; acetone; acetonitrile;

Reference yield:

: 213413-28-6
(1R,4R)-4-(iodomethyl)cyclohexanecarboxylic acid methyl ester

: 1456626-25-7
6-[bis(carboxymethyl)amino]-6-[(1R,4R)-4-[(didecylamino)-carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H) diacetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium nitrite; 3,5-dihydroxyphenol / dimethyl sulfoxide / 48 h / 20 °C / Inert atmosphere

2.1: ethanol / 1.5 h / 60 - 80 °C

2.2: 6 h / 80 °C

3.1: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran; methanol / 11 h / 40 °C

4.1: potassium carbonate; sodium sulfate / acetonitrile; ethyl acetate / 1 h / 80 °C

5.1: water; sodium hydroxide / isopropyl alcohol / 5.5 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 49 h / 0 - 20 °C

7.1: N-ethyl-N,N-diisopropylamine / chloroform / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With 3,5-dihydroxyphenol; 5%-palladium/activated carbon; water; hydrogen; potassium carbonate; sodium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol; acetonitrile;