2-((2S,4S)-1-(4-(4-(benzyloxy)-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Base Information

Chemical Name:2-((2S,4S)-1-(4-(4-(benzyloxy)-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile
CAS No.:1283146-32-6
Molecular Formula:C₂₇H₂₅F₃N₂O₂
Molecular Weight:466.503
Hs Code.:

Synonyms:2-((2S,4S)-1-(4-(4-(benzyloxy)-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

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Chemical Property of 2-((2S,4S)-1-(4-(4-(benzyloxy)-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

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Technology Process of 2-((2S,4S)-1-(4-(4-(benzyloxy)-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

There total 7 articles about 2-((2S,4S)-1-(4-(4-(benzyloxy)-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1283146-31-5
2-((2S,4S)-1-(4-hydroxyphenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

: 847560-49-0
[4-(benzyloxy)-2-methylphenyl]boronic acid

: 1283146-32-6
2-((2S,4S)-1-(4-(4-(benzyloxy)-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: With triethylamine; copper diacetate; In dichloromethane; at 20 ℃; for 3h; Molecular sieve;

Reference yield:

: 1283146-30-4
2-((2S,4S)-1-(4-(benzyloxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

: 1283146-32-6
2-((2S,4S)-1-(4-(4-(benzyloxy)-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate; acetic acid / 760.05 Torr

2: copper diacetate; pyridine / dichloromethane / 3 h / Molecular sieve

With pyridine; palladium 10% on activated carbon; hydrogen; copper diacetate; In dichloromethane; acetic acid; ethyl acetate;
DOI:10.1021/acs.jmedchem.6b01559

Reference yield:

: 1283146-29-1
((2S,4S)-1-(4-(benzyloxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

: 1283146-32-6
2-((2S,4S)-1-(4-(4-(benzyloxy)-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 0 °C

2: dimethyl sulfoxide / 50 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate; acetic acid / 760.05 Torr

4: copper diacetate; pyridine / dichloromethane / 3 h / Molecular sieve

With pyridine; palladium 10% on activated carbon; hydrogen; copper diacetate; triethylamine; In dichloromethane; acetic acid; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/acs.jmedchem.6b01559