O-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-ylmethyl]-hydroxylamine

Base Information

Chemical Name:O-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-ylmethyl]-hydroxylamine
CAS No.:168018-40-4
Molecular Formula:C₃₀H₃₀ClN₃O₂S
Molecular Weight:532.106
Hs Code.:

Synonyms:O-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-ylmethyl]-hydroxylamine

Suppliers and Price of O-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-ylmethyl]-hydroxylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of O-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-ylmethyl]-hydroxylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of O-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-ylmethyl]-hydroxylamine

There total 11 articles about O-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-ylmethyl]-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 168018-39-1
2-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-ylmethoxy]-isoindole-1,3-dione

: 168018-40-4
O-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-ylmethyl]-hydroxylamine

Guidance literature:: With hydrazine hydrate; In 1,4-dioxane; ethanol; for 0.5h; Heating;
DOI:10.1016/S0968-0896(96)00265-9

Reference yield:

: 4377-41-7
2-Chloromethylquinoline

: 168018-40-4
O-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-ylmethyl]-hydroxylamine

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / dimethylformamide / 14 h / 50 °C

2: 72 percent / 1 N aq. NaOH / methanol; dioxane / 6 h / 50 °C

3: triethylamine / tetrahydrofuran / 0.33 h / -15 - -10 °C

4: NaBH₄ / tetrahydrofuran / -10 - 0 °C

5: 82 percent / triphenylphosphine, diethylazodicarboxylate / tetrahydrofuran / 15 h / Ambient temperature

6: 98 percent / hydrazine hydrate / ethanol; dioxane / 0.5 h / Heating

With sodium hydroxide; sodium tetrahydroborate; potassium carbonate; hydrazine hydrate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(96)00265-9

Reference yield:

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 168018-40-4
O-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-ylmethyl]-hydroxylamine

Guidance literature:: Multi-step reaction with 9 steps

1: 34 percent / 2-methyl-propan-2-ol / 48 h / Heating

2: 1.) NaH / 1.) DMF, RT, 15 min, 2.) DMF, RT, 14 h

3: AlCl₃, t-BuSH / CH₂Cl₂ / 0.75 h / 0 °C

4: K₂CO₃ / dimethylformamide / 14 h / 50 °C

5: 72 percent / 1 N aq. NaOH / methanol; dioxane / 6 h / 50 °C

6: triethylamine / tetrahydrofuran / 0.33 h / -15 - -10 °C

7: NaBH₄ / tetrahydrofuran / -10 - 0 °C

8: 82 percent / triphenylphosphine, diethylazodicarboxylate / tetrahydrofuran / 15 h / Ambient temperature

9: 98 percent / hydrazine hydrate / ethanol; dioxane / 0.5 h / Heating

With sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; sodium hydride; potassium carbonate; hydrazine hydrate; 2-methylpropan-2-thiol; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0968-0896(96)00265-9