(1S,2R,6R)-6-(4-Chloro-phenyl)-2-hydroxy-4-oxo-2-phenyl-cyclohexanecarboxylic acid benzyl ester

Base Information

• Chemical Name: (1S,2R,6R)-6-(4-Chloro-phenyl)-2-hydroxy-4-oxo-2-phenyl-cyclohexanecarboxylic acid benzyl ester
• CAS No.: 688800-80-8
• Molecular Formula: C₂₆H₂₃ClO₄
• Molecular Weight: 434.919

Synonyms:(1S,2R,6R)-6-(4-Chloro-phenyl)-2-hydroxy-4-oxo-2-phenyl-cyclohexanecarboxylic acid benzyl ester

Chemical Property of (1S,2R,6R)-6-(4-Chloro-phenyl)-2-hydroxy-4-oxo-2-phenyl-cyclohexanecarboxylic acid benzyl ester

Chemical Property:

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Technology Process of (1S,2R,6R)-6-(4-Chloro-phenyl)-2-hydroxy-4-oxo-2-phenyl-cyclohexanecarboxylic acid benzyl ester

There total 2 articles about (1S,2R,6R)-6-(4-Chloro-phenyl)-2-hydroxy-4-oxo-2-phenyl-cyclohexanecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3E)-4-(4-chlorophenyl)-3-buten-2-one (30626-03-0) + benzyl benzoylacetate (63888-22-2) → 6-(4-chloro-phenyl)-2-hydroxy-4-oxo-2-phenyl-cyclohexanecarboxylic acid benzyl ester + (1S,2R,6R)-6-(4-Chloro-phenyl)-2-hydroxy-4-oxo-2-phenyl-cyclohexanecarboxylic acid benzyl ester (688800-80-8)

Guidance literature:

With 4-(S)-benzyl-1-methylimidazolidine-2-carboxylic acid; In ethanol; at 20 ℃; for 95h;

DOI:10.1002/anie.200353364

Reference yield:

(3E)-4-(4-chlorophenyl)-3-buten-2-one (30626-03-0) + benzyl benzoylacetate (63888-22-2) → 6-(4-chloro-phenyl)-2-hydroxy-4-oxo-2-phenyl-cyclohexanecarboxylic acid benzyl ester + (1R,2S,6S)-6-(4-Chloro-phenyl)-2-hydroxy-4-oxo-2-phenyl-cyclohexanecarboxylic acid benzyl ester + (1S,2R,6R)-6-(4-Chloro-phenyl)-2-hydroxy-4-oxo-2-phenyl-cyclohexanecarboxylic acid benzyl ester (688800-80-8)

Guidance literature:

With 4-(S)-benzyl-1-methylimidazolidine-2-carboxylic acid; In ethanol; at 20 ℃; for 240h;

DOI:10.1002/anie.200353364

Reference yield:

(1S,2R,6R)-6-(4-Chloro-phenyl)-2-hydroxy-4-oxo-2-phenyl-cyclohexanecarboxylic acid benzyl ester (688800-80-8) → CCDC-224449

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / urea; TFAA; aq. H₂O₂ / CH₂Cl₂ / 1 h / 20 °C

2: 72 percent / LiOH / 0.5 h / 20 °C

With lithium hydroxide; dihydrogen peroxide; urea; trifluoroacetic anhydride; In dichloromethane; 1: Baeyer-Villiger oxidation;

DOI:10.1002/anie.200353364

upstream raw materials:

(3E)-4-(4-chlorophenyl)-3-buten-2-one

benzyl benzoylacetate

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