(2R,3aS,9aR)-2-(2,3-Difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene

Base Information

Chemical Name:(2R,3aS,9aR)-2-(2,3-Difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene
CAS No.:705281-26-1
Molecular Formula:C₂₃H₃₈F₂O₄Si₂
Molecular Weight:472.72
Hs Code.:

Synonyms:(2R,3aS,9aR)-2-(2,3-Difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene

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Chemical Property of (2R,3aS,9aR)-2-(2,3-Difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene

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Technology Process of (2R,3aS,9aR)-2-(2,3-Difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene

There total 3 articles about (2R,3aS,9aR)-2-(2,3-Difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3aS,9aR)-2-(2,3-Difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-ol

: 705281-26-1
(2R,3aS,9aR)-2-(2,3-Difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene

: (2S,3aS,9aR)-2-(2,3-Difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 7h;
DOI:10.1021/ja049961u

Reference yield:

: 38573-88-5
1-bromo-2,3-difluorobenzene

: 705281-26-1
(2R,3aS,9aR)-2-(2,3-Difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 °C

1.2: tetrahydrofuran; hexane / 1 h / -78 °C

2.1: Et₃SiH; BF₃*Et₂O / CH₂Cl₂ / 7 h / -78 °C

With triethylsilane; n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja049961u

Reference yield:

: 169526-37-8
(6aR,9aS)-2,2,4,4-tetraisopropyltetrahydro-8H-furo[3,2-f ][1,3,5,2,4]trioxadisilocin-8-one

: 705281-26-1
(2R,3aS,9aR)-2-(2,3-Difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 °C

1.2: tetrahydrofuran; hexane / 1 h / -78 °C

2.1: Et₃SiH; BF₃*Et₂O / CH₂Cl₂ / 7 h / -78 °C

With triethylsilane; n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja049961u