1-ethoxy-2,2-difluoro-2-((2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl)ethanol

Base Information

Chemical Name:1-ethoxy-2,2-difluoro-2-((2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl)ethanol
CAS No.:1616619-35-2
Molecular Formula:C₃₈H₄₂F₂O₇
Molecular Weight:648.744
Hs Code.:

Synonyms:1-ethoxy-2,2-difluoro-2-((2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl)ethanol

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Chemical Property of 1-ethoxy-2,2-difluoro-2-((2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl)ethanol

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Technology Process of 1-ethoxy-2,2-difluoro-2-((2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl)ethanol

There total 8 articles about 1-ethoxy-2,2-difluoro-2-((2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 2,2-difluoro-2-((3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl)acetate

: 1616619-35-2
1-ethoxy-2,2-difluoro-2-((2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl)ethanol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 1h; Inert atmosphere;

Reference yield:

: ethyl 2,2-difluoro-2-((3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-2-chlorotetrahydro-2H-pyran-2-yl)acetate

: 1616619-35-2
1-ethoxy-2,2-difluoro-2-((2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: tri-n-butyl-tin hydride; 1,1'-azobis (cyclohexanecarbonitrile) / toluene / 1 h / Reflux; Inert atmosphere

2: diisobutylaluminium hydride / toluene / 1 h / -78 °C / Inert atmosphere

With 1,1'-azobis (cyclohexanecarbonitrile); tri-n-butyl-tin hydride; diisobutylaluminium hydride; In toluene;

Reference yield:

: ethyl 2,2-difluoro-2-((3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-2-hydroxytetrahydro-2H-pyran-2-yl)acetate

: 1616619-35-2
1-ethoxy-2,2-difluoro-2-((2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; thionyl chloride / dichloromethane / 0.17 h / 0 - 5 °C / Inert atmosphere

2: tri-n-butyl-tin hydride; 1,1'-azobis (cyclohexanecarbonitrile) / toluene / 1 h / Reflux; Inert atmosphere

3: diisobutylaluminium hydride / toluene / 1 h / -78 °C / Inert atmosphere

With pyridine; thionyl chloride; 1,1'-azobis (cyclohexanecarbonitrile); tri-n-butyl-tin hydride; diisobutylaluminium hydride; In dichloromethane; toluene;