4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid

Base Information

• Chemical Name: 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid
• CAS No.: 6935-15-5
• Molecular Formula: C15H13NO5
• Molecular Weight: 287.272
• Mol file: 6935-15-5.mol

Synonyms:

Chemical Property of 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid

Chemical Property:

• Vapor Pressure: 6.75E-09mmHg at 25°C
• Boiling Point: 450.3°C at 760 mmHg
• Flash Point: 226.2°C
• Density: 1.432g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid

There total 3 articles about 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-Aminosalicylic acid (65-49-6) + benzyl chloroformate (501-53-1,94274-21-2) → 4‐{[(benzyloxy)carbonyl]amino}‐2‐hydroxybenzoic acid (6935-15-5)

Guidance literature:

With sodium hydrogencarbonate; In methanol; at 20 ℃; for 2.5h;

DOI:10.1002/chem.201200610

Reference yield: 68.0%

sodium p-aminosalicylate (133-10-8) + benzyl chloroformate (501-53-1,94274-21-2) → 4‐{[(benzyloxy)carbonyl]amino}‐2‐hydroxybenzoic acid (6935-15-5)

Guidance literature:

sodium p-aminosalicylate; benzyl chloroformate; With sodium hydroxide; In water; toluene; at 0 - 20 ℃; for 48h;

With hydrogenchloride; In water; toluene; at 0 ℃;

Reference yield:

→ 4‐{[(benzyloxy)carbonyl]amino}‐2‐hydroxybenzoic acid (6935-15-5)

Guidance literature:

/BRN= 3383300/;

upstream raw materials:

sodium p-aminosalicylate

benzyl chloroformate

4-Aminosalicylic acid

Refernces

• 1、 Dawadi, Surendra,Kordus, Shannon L.,Baughn, Anthony D.,Aldrich, Courtney C.. "Synthesis and analysis of bacterial folate metabolism intermediates and antifolates". supporting information. p. 5220 - 5223. Retrieved 2017/11/06.
• 2、 -. "Antibacterial Agents". Page/Page column 49. . Retrieved 2009/01/20.