1-(2-(5-benzyloxy-1H-indol-3-yl)ethyl)-3-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]urea

Base Information

Chemical Name:1-(2-(5-benzyloxy-1H-indol-3-yl)ethyl)-3-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]urea
CAS No.:265129-59-7
Molecular Formula:C₃₀H₃₅N₅O₃
Molecular Weight:513.64
Hs Code.:

Synonyms:1-(2-(5-benzyloxy-1H-indol-3-yl)ethyl)-3-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]urea

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Chemical Property of 1-(2-(5-benzyloxy-1H-indol-3-yl)ethyl)-3-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]urea

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Technology Process of 1-(2-(5-benzyloxy-1H-indol-3-yl)ethyl)-3-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]urea

There total 2 articles about 1-(2-(5-benzyloxy-1H-indol-3-yl)ethyl)-3-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 20776-45-8
5-benzyloxytryptamine

: imidazole-1-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide

: 265129-59-7
1-(2-(5-benzyloxy-1H-indol-3-yl)ethyl)-3-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]urea

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 12h;
DOI:10.1021/jm9811054

Reference yield:

: 4-methoxy-3-(4-methylpiperazin-1-yl)aniline dihydrochloride

: 265129-59-7
1-(2-(5-benzyloxy-1H-indol-3-yl)ethyl)-3-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]urea

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / acetonitrile / 4 h / 20 °C

2: 77 percent / Et₃N / acetonitrile / 12 h / 20 °C

With triethylamine; In acetonitrile; 1: Condensation / 2: Substitution;
DOI:10.1021/jm9811054