1-{[(2S,3R,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methyl}-4-methylpiperazine

Base Information

Chemical Name:1-{[(2S,3R,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methyl}-4-methylpiperazine
CAS No.:1619984-28-9
Molecular Formula:C₂₉H₄₆N₂O₃
Molecular Weight:470.696
Hs Code.:

Synonyms:1-{[(2S,3R,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methyl}-4-methylpiperazine

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Chemical Property of 1-{[(2S,3R,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methyl}-4-methylpiperazine

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Technology Process of 1-{[(2S,3R,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methyl}-4-methylpiperazine

There total 11 articles about 1-{[(2S,3R,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methyl}-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 109-01-3
1-methyl-piperazine

: 1619984-23-4
[(2S,3R,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methyl methanesulfonate

: 1619984-28-9
1-{[(2S,3R,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methyl}-4-methylpiperazine

Guidance literature:: 1-methyl-piperazine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 1h; Cooling with ice; Inert atmosphere;

[(2S,3R,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methyl methanesulfonate; In N,N-dimethyl-formamide; mineral oil; at 50 ℃; Cooling with ice;

Reference yield:

: (1S,2R,4aS,8aS)-1-[(3,5-dimethoxyphenyl)(hydroxy)methyl]-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

: 1619984-28-9
1-{[(2S,3R,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methyl}-4-methylpiperazine

Guidance literature:: Multi-step reaction with 10 steps

1.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C

2.1: tin(IV) chloride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere

3.2: 1.33 h / 0 - 65 °C

4.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C

5.1: sodium hydroxide / tetrahydrofuran; methanol / 3.5 h / 80 °C

6.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

6.2: 1 h / 20 °C

7.1: hydrogenchloride / tetrahydrofuran / 0.5 h / Reflux

8.1: sodium tetrahydroborate; methanol / 0.58 h / 20 °C / Inert atmosphere; Cooling with ice

9.1: pyridine / 1.5 h / Cooling with ice; Inert atmosphere

10.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / Cooling with ice; Inert atmosphere

10.2: 50 °C / Cooling with ice

With pyridine; hydrogenchloride; methanol; sodium tetrahydroborate; borane-THF; potassium tert-butylate; tin(IV) chloride; sodium hydride; pyridinium chlorochromate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1619983-08-2
[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](3,5-dimethoxyphenyl)methanone

: 1619984-28-9
1-{[(2S,3R,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methyl}-4-methylpiperazine

Guidance literature:: Multi-step reaction with 7 steps

1.1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere

1.2: 1.33 h / 0 - 65 °C

2.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran; methanol / 3.5 h / 80 °C

4.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4.2: 2 h

5.1: borane-THF / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

5.2: 2 h / 20 °C / Cooling with ice

6.1: pyridine / 1.5 h / Cooling with ice; Inert atmosphere

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / Cooling with ice; Inert atmosphere

7.2: 50 °C / Cooling with ice

With pyridine; borane-THF; potassium tert-butylate; sodium hydride; pyridinium chlorochromate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; 4.1: |Wittig Olefination;