diethyl 2-benzyl-2-(N-((R)-α-methylbenzyl)amino)malonate hydrochloride

Base Information

Chemical Name:diethyl 2-benzyl-2-(N-((R)-α-methylbenzyl)amino)malonate hydrochloride
CAS No.:1393737-25-1
Molecular Formula:C₂₂H₂₇NO₄*ClH
Molecular Weight:405.922
Hs Code.:

Synonyms:diethyl 2-benzyl-2-(N-((R)-α-methylbenzyl)amino)malonate hydrochloride

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Chemical Property of diethyl 2-benzyl-2-(N-((R)-α-methylbenzyl)amino)malonate hydrochloride

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Technology Process of diethyl 2-benzyl-2-(N-((R)-α-methylbenzyl)amino)malonate hydrochloride

There total 1 articles about diethyl 2-benzyl-2-(N-((R)-α-methylbenzyl)amino)malonate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1393737-33-1
diethyl 2-benzyl-2-(N-((R)-α-methylbenzyl)amino)malonate

: 1393737-25-1
diethyl 2-benzyl-2-(N-((R)-α-methylbenzyl)amino)malonate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; diethyl ether;
DOI:10.1016/j.tet.2012.06.090

Reference yield: 97.0%

: 1393737-25-1
diethyl 2-benzyl-2-(N-((R)-α-methylbenzyl)amino)malonate hydrochloride

: 1393737-33-1
diethyl 2-benzyl-2-(N-((R)-α-methylbenzyl)amino)malonate

Guidance literature:: With sodium hydrogencarbonate; In chloroform; water; Saturated solution;
DOI:10.1016/j.tet.2012.06.090

Reference yield:

: 1393737-25-1
diethyl 2-benzyl-2-(N-((R)-α-methylbenzyl)amino)malonate hydrochloride

: (R)-4-benzyl-2-oxo-4-oxazolidinecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / chloroform; water / Saturated solution

2.1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / Cooling with ice

2.2: 2 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 6 h / 20 °C

3.2: 15 h / 20 °C

4.1: trifluorormethanesulfonic acid; methoxybenzene / nitromethane / 6 h / 50 °C

5.1: sodium periodate; rhodium(III) chloride hydrate / tetrachloromethane; water; acetonitrile / 5 h / 20 °C

With sodium periodate; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; rhodium(III) chloride hydrate; sodium hydrogencarbonate; methoxybenzene; triethylamine; In tetrahydrofuran; tetrachloromethane; diethyl ether; nitromethane; chloroform; water; acetonitrile;
DOI:10.1016/j.tet.2012.06.090