tert-butyl 4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]piperazine-1-carboxylate
CAS No.:1143577-38-1
Molecular Formula:C₁₉H₂₂F₂N₄O₂
Molecular Weight:376.406
Hs Code.:

Synonyms:tert-butyl 4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]piperazine-1-carboxylate

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Technology Process of tert-butyl 4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]piperazine-1-carboxylate

There total 3 articles about tert-butyl 4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 203519-88-4
4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester

: 144025-03-6
2,4-difluorophenylboronic acid

: 1143577-38-1
tert-butyl 4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]piperazine-1-carboxylate

Guidance literature:: With sodium carbonate; In water; toluene; at 20 - 100 ℃;

Reference yield:

: 221050-88-0
4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester

: 1143577-38-1
tert-butyl 4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 100 °C / Inert atmosphere

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In toluene; 1: |Buchwald-Hartwig Coupling / 2: |Suzuki Coupling;
DOI:10.1016/j.bmc.2013.12.023

Reference yield:

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1143577-38-1
tert-butyl 4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 4 h / 20 °C

2: sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 100 °C / Inert atmosphere

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In N,N-dimethyl-formamide; toluene; 2: |Buchwald-Hartwig Coupling / 3: |Suzuki Coupling;
DOI:10.1016/j.bmc.2013.12.023