3-methyl-N-phenyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide

Base Information

Chemical Name:3-methyl-N-phenyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
CAS No.:1028253-25-9
Molecular Formula:C₃₆H₄₂ClN₅O₇S
Molecular Weight:724.278
Hs Code.:

3-methyl-N-phenyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide

Synonyms:3-methyl-N-phenyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide

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Chemical Property of 3-methyl-N-phenyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide

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Technology Process of 3-methyl-N-phenyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide

There total 5 articles about 3-methyl-N-phenyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1028252-93-8
(2S,4R)-4-(7-chloro-4-methoxyisoquinolin-1-yloxy)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)pyrrolidine-2-carboxamide

: 400777-56-2
2-phenylamino-3,3-dimethylbutanoic acid

: 1028253-26-0
3-methyl-N-phenyl-D-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide

: 1028253-25-9
3-methyl-N-phenyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1028253-26-0
3-methyl-N-phenyl-D-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide

: 1028253-25-9
3-methyl-N-phenyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; potassium carbonate / N,N-dimethyl acetamide / 90 - 130 °C

1.2: pH 5

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0 - 20 °C

With copper(l) iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 20859-02-3
L-tert-Leucine

: 1028253-26-0
3-methyl-N-phenyl-D-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide

: 1028253-25-9
3-methyl-N-phenyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; potassium carbonate / N,N-dimethyl acetamide / 90 - 130 °C

1.2: pH 5

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0 - 20 °C

With copper(l) iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl acetamide;