Technology Process of ethyl 6-(7-formylheptyl)-2-methoxybenzoate
There total 16 articles about ethyl 6-(7-formylheptyl)-2-methoxybenzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate; dimethyl sulfoxide;
at 90 ℃;
for 11h;
DOI:10.1248/cpb.49.18
- Guidance literature:
-
Multi-step reaction with 6 steps
1: p-toluenesulfonic acid / CH2Cl2 / 1.5 h
2: 1.) DMSO; 2.) oxalyl chloride, triethylamine / 1.) CH2Cl2, -50 deg C, 5 min; 2.) CH2Cl2, -50 deg C 20 min, rt
3: potassium t-butoxide / 1.) THF-HMPA, -60 deg C, 30 min; 2.) -20 deg C 5 min, rt overnight
4: 95 percent / p-toluenesulfonic acid / methanol / 2 h / Ambient temperature
5: hydrogen / Pt-C / ethyl acetate
6: 1.) DMSO; 2.) oxalyl chloride, triethylamine / 1.) CH2Cl2, -78 deg C, 5 min; 2.) CH2Cl, -78 deg C 5 min, rt
With
oxalyl dichloride; potassium tert-butylate; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
platinum on activated charcoal;
In
methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(01)81629-X
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium t-butoxide / 1.) THF-HMPA, -60 deg C, 30 min; 2.) -20 deg C 5 min, rt overnight
2: 95 percent / p-toluenesulfonic acid / methanol / 2 h / Ambient temperature
3: hydrogen / Pt-C / ethyl acetate
4: 1.) DMSO; 2.) oxalyl chloride, triethylamine / 1.) CH2Cl2, -78 deg C, 5 min; 2.) CH2Cl, -78 deg C 5 min, rt
With
oxalyl dichloride; potassium tert-butylate; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
platinum on activated charcoal;
In
methanol; ethyl acetate;
DOI:10.1016/S0040-4020(01)81629-X
