(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile

Base Information

Chemical Name:(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile
CAS No.:1361504-17-7
Molecular Formula:C₂₀H₂₀BrN₃
Molecular Weight:382.303
Hs Code.:

Synonyms:(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile

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Technology Process of (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile

There total 3 articles about (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 19472-74-3
2-(2-bromophenyl)acetonitrile

: 27913-99-1
4-(4-methylpiperazin-1-yl) benzaldehyde

: 1361504-17-7
(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile

Guidance literature:: With pyrrolidine; In methanol; at 60 ℃;
DOI:10.1021/jm2017122

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1361504-17-7
(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 100 °C

2: pyrrolidine / methanol / 60 °C

With pyrrolidine; potassium carbonate; In methanol; dimethyl sulfoxide; 2: Knoevenagel condensation;
DOI:10.1021/jm2017122

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1361504-17-7
(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 100 °C

2: pyrrolidine / methanol / 60 °C

With pyrrolidine; potassium carbonate; In methanol; dimethyl sulfoxide; 2: Knoevenagel condensation;
DOI:10.1021/jm2017122